ArticleParasitology research2007
In vitro antileishmanial activity of resveratrol and its hydroxylated analogues against Leishmania major promastigotes and amastigotes.
Article in Parasitology research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 82 citations in OpenAlex.
- Biological Activity of Stilbenoids Against Fungal, Parasitic, and Viral Pathogens.Molecules (Basel, Switzerland) · 2026Review
- Combination Therapy and Phytochemical-Loaded Nanosytems for the Treatment of Neglected Tropical Diseases.Pharmaceutics · 2024Review
- Between the Devil and the Deep Blue Sea-Resveratrol, Sulfotransferases and Sulfatases-A Long and Turbulent Journey from Intestinal Absorption to Target Cells.Molecules (Basel, Switzerland) · 2023Review
- Nanomedicine-based strategies to improve treatment of cutaneous leishmaniasis.Royal Society open science · 2022Article
- Anti-blastocystosis activity of antioxidant coated ZIF-8 combined with mesoporous silicas MCM-41 and KIT-6.Scientific reports · 2022Article
- Anti-leishmanial effects of resveratrol and resveratrol nanoemulsion on Leishmania major.BMC microbiology · 2022Article
- Nutraceuticals in the Prevention of Viral Infections, including COVID-19, among the Pediatric Population: A Review of the Literature.International journal of molecular sciences · 2021Review
- Natural Products That Target the Arginase inMicroorganisms · 2021Review
- SystematicFrontiers in chemistry · 2021Article
- Improvement of Mitochondrial Activity and Fibrosis by Resveratrol Treatment in Mice withBiomolecules · 2019Article
- Resveratrol: A miraculous natural compound for diseases treatment.Food science & nutrition · 2018Review
- Therapeutic Versatility of Resveratrol Derivatives.Nutrients · 2017Review
- Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression.International journal for parasitology. Drugs and drug resistance · 2017Article
- Bismuth(III) α-hydroxy carboxylates: highly selective toxicity of glycolates towards Leishmania major.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2015Article
- Resveratrol Demonstrates Antimicrobial Effects Against Propionibacterium acnes In Vitro.Dermatology and therapy · 2014Article
- Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.Chemical reviews · 2014Review
- Resveratrol is active against Leishmania amazonensis: in vitro effect of its association with Amphotericin B.Antimicrobial agents and chemotherapy · 2014Article
- Are reactive oxygen species always detrimental to pathogens?Antioxidants & redox signaling · 2014Review
- Hydrogenosome metabolism is the key target for antiparasitic activity of resveratrol against Trichomonas vaginalis.Antimicrobial agents and chemotherapy · 2013Article
- Differences in the in vitro susceptibility to resveratrol and other chemical compounds among several Philasterides dicentrarchi isolates from turbot.Parasitology research · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resveratrol, a natural phytoalexin found mainly in grapes, possesses a variety of beneficial activities including anticancer, antimicrobial and antiviral. However, there is no information about its effects on kinetoplastid parasites such as Leishmania. Leishmania is a human pathogen responsible for a spectrum of diseases known as leishmaniases and a significant health problem in many parts of the world. In this study, we investigated effects of resveratrol and its hydroxylated analogues on Leishmania major, a causative agent of zoonotic cutaneous leishmaniasis in the Old World. Resveratrol showed antileishmanial activity against promastigotes in vitro and, more importantly, was effective against intracellular amastigotes, a parasite life stage infectious in humans, as detected in in vitro macrophage assay. The hydroxylated stilbenes tested in this study also showed antileishmanial activity against promastigotes, the most promising being 3,4,4',5'-tetrahydroxy-trans-stilbene. This compound showed excellent antileishmanial activity against extracellular promastigotes in vitro but not intracellular amastigotes. Our results suggest that resveratrol may be useful as a therapeutic agent to treat leishmaniasis and warrant its further assessment in animal models of disease.
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