ArticlePlanta2007
Characterization of rice tryptophan decarboxylases and their direct involvement in serotonin biosynthesis in transgenic rice.
Article in Planta, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed.
- From Abiotic Stress to Emerging Environmental Pollutants: Expanding Roles of Melatonin and NO in Plant Defense.International journal of molecular sciences · 2026Review
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- The genome of the medicinal plant Uncaria rhynchophylla provides new insights into monoterpenoid indole alkaloid metabolism and its molecular regulatory mechanism.Molecular horticulture · 2026Article
- Functional characterization of AtAAS as a 5-hydroxytryptophan decarboxylase linking serotonin formation to melatonin metabolism inFrontiers in plant science · 2026Article
- Auxin Biosynthesis, Transport, Signaling, and Its Roles in Plant Leaf Morphogenesis.Plants (Basel, Switzerland) · 2025Review
- Alternative polyadenylation and metabolic profiling in young panicle development of hybrid rice and its parents.Rice (New York, N.Y.) · 2025Article
- Integrated Analysis of Physiological Responses and Transcriptome of Cotton Seedlings Under Drought Stress.International journal of molecular sciences · 2025Article
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- CRISPR/Cas9-mediated editing of uORFs in the tryptophan decarboxylase gene SlTDC1 enhances serotonin biosynthesis in tomato.Plant biotechnology journal · 2025Article
- Identification, characterization, and expression of Oryza sativa tryptophan decarboxylase genes associated with fluroxypyr-meptyl metabolism.The plant genome · 2025Article
- On the Biosynthesis of Bioactive Tryptamines in Black Cohosh (Plants (Basel, Switzerland) · 2025Article
- Views and perspectives on the indoleamines serotonin and melatonin in plants: past, present and future.Plant signaling & behavior · 2024Review
- Dynamic metabolite QTL analyses provide novel biochemical insights into kernel development and nutritional quality improvement in common wheat.Plant communications · 2024Article
- Understanding the mechanism of red light-induced melatonin biosynthesis facilitates the engineering of melatonin-enriched tomatoes.Nature communications · 2023Article
- Phytomelatonin: A key regulator of redox and phytohormones signaling against biotic/abiotic stresses.Redox biology · 2023Review
- Biosynthetic Pathways of Hormones in Plants.Metabolites · 2023Review
- Straw Mulch Induced Indoleamines Alleviate Reproductive Depression in Cold Sensitive Hazelnut Cultivars.Plants (Basel, Switzerland) · 2023Article
- Molecular Cloning and Characterization of a SerotoninInternational journal of environmental research and public health · 2023Article
- Integrated Physiological, Transcriptomic, and Proteomic Analyses Reveal the Regulatory Role of Melatonin in Tomato Plants' Response to Low Night Temperature.Antioxidants (Basel, Switzerland) · 2022Article
- Nitric Oxide Is Essential for Melatonin to Enhance Nitrate Tolerance of Cucumber Seedlings.Molecules (Basel, Switzerland) · 2022Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
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Abstract
L-Tryptophan decarboxylase (TDC) and L-tyrosine decarboxylase (TYDC) belong to a family of aromatic L-amino acid decarboxylases and catalyze the conversion of tryptophan and tyrosine into tryptamine and tyramine, respectively. The rice genome has been shown to contain seven TDC or TYDC-like genes. Three of these genes for which cDNA clones were available were characterized to assign their functions using heterologous expression in Escherichia coli and rice (Oryza sativa cv. Dongjin). The purified products of two of the genes were expressed in E. coli and exhibited TDC activity, whereas the remaining gene could not be expressed in E. coli. The recombinant TDC protein with the greatest TDC activity showed a K (m) of 0.69 mM for tryptophan, and its activity was not inhibited by phenylalanine or tyrosine, indicating a high level of substrate specificity toward tryptophan. The ectopic expression of the three cDNA clones in rice led to the abundant production of the products of the encoded enzymes, tyramine and tryptamine. The overproduction of TYDC resulted in stunted growth and a lack of seed production due to tyramine accumulation, which increased as the plant aged. In contrast, transgenic plants that produced TDC showed a normal phenotype and contained 25-fold and 11-fold higher serotonin in the leaves and seeds, respectively, than the wild-type plants. The overproduction of either tyramine or serotonin was not strongly related to the enhanced synthesis of tyramine or serotonin derivatives, such as feruloyltyramine and feruloylserotonin, which are secondary metabolites that act as phytoalexins in plants.
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