ArticleArthritis and rheumatism2007
Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model.
Article in Arthritis and rheumatism, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Overview on the Link Between the Complement System and Auto-Immune Articular and Pulmonary Disease.Open access rheumatology : research and reviews · 2023Review
- Review
- Plasmacytoid dendritic cells in the eye.Progress in retinal and eye research · 2021Review
- A time-course microarray data analysis reveals consistent dysregulated genes and upstream microRNAs in autoantibody-mediated arthritis.Journal of orthopaedic surgery and research · 2017Article
- K/BxN Serum-Transfer Arthritis as a Model for Human Inflammatory Arthritis.Frontiers in immunology · 2016Review
- CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis.Arthritis research & therapy · 2015Article
- Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- KRN/I-Ag7 mouse arthritis is independent of complement C3.Journal of clinical immunology · 2011Article
- The synovium in rheumatoid arthritis.The open rheumatology journal · 2011Article
- Immune cell-derived c3 is required for autoimmune diabetes induced by multiple low doses of streptozotocin.Diabetes · 2010Article
- Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1.Arthritis and rheumatism · 2010Article
- Antigen-specific tolerogenic and immunomodulatory strategies for the treatment of autoimmune arthritis.Seminars in arthritis and rheumatism · 2008Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveFor the inflammation characteristic of rheumatoid arthritis, the relative contribution of mediators produced locally in the synovium versus those circulating systemically is unknown. Complement factor C3 is made in rheumatoid synovium and has been proposed to be a crucial driver of inflammation. The aim of this study was to test, in a mouse model of rheumatoid arthritis, whether C3 synthesized within the synovium is important in promoting inflammation.
methodsRadiation bone marrow chimeras between normal and C3(-/-) mice were constructed in order to generate animals that expressed or lacked expression of C3 only in hematopoietic cells. Parabiotic mice were made by surgically linking C3(-/-) mice to irradiated wild-type mice to obtain animals having C3 only in the circulation. Arthritis was induced by injection of serum from arthritic K/BxN mice.
resultsIn bone marrow chimeras, synthesis of C3 by radioresistant cells was necessary and sufficient to confer susceptibility to serum-transferred arthritis. Parabionts having C3 only in the circulation remained sensitive to arthritis induction, and the cartilage of these arthritic mice contained deposits of C3.
conclusionIn a mouse model in which the alternative pathway of complement activation is critical to the induction of arthritis by autoantibodies, circulating C3 was necessary and sufficient for arthritis induction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.