Evidence map›Paper›PMID 17763333›Full record

ArticleThe Journal of infectious diseases2007

Unique lipid a modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis.

Robert K Ernst, Samuel M Moskowitz, Julia C Emerson, Gretchen M Kraig, Kristin N Adams, Megan D Harvey, Bonnie Ramsey, David P Speert, Jane L Burns, Samuel I Miller

Abstract readMulticenter Study
In one paragraph

Article in The Journal of infectious diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Deep-Learning Driven Identification of Novel Antimicrobial Peptides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  6. LpxR and PagL expression in live attenuated auxotrophicFrontiers in cellular and infection microbiology · 2025
    Article
  7. Article
  8. NovelMicrobiology spectrum · 2024
    Article
  9. Article
  10. Unravelling the mechanisms causing murepavadin resistance inFrontiers in cellular and infection microbiology · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Monoclonal antibodies against lipopolysaccharide protect againstFrontiers in cellular and infection microbiology · 2023
    Article
  17. Article
  18. Review
  19. Review
  20. Adaptation and Evolution of Pathogens in the Cystic Fibrosis Lung.Journal of the Pediatric Infectious Diseases Society · 2022
    Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Robert K ErnstDepartment of Medicine, University of Washington, Seattle, WA 98195, USA. rkernst@u.washington.edu
Samuel M Moskowitz
Julia C Emerson
Gretchen M Kraig
Kristin N Adams
Megan D Harvey
Bonnie Ramsey
David P Speert
Jane L Burns
Samuel I Miller

Funding

ZIPRASIDONE IN NORMAL HEPATIC FUNCTION SUBJECTS &IN HEPATIC DYSFUCTIN SUBJECTSM01RR000037 · NCRR · UNIVERSITY OF WASHINGTON · PI MCDONALD, RUTH C · 1985 to 2007
$33.8M
Pseudomonas aeruginosa lipid AR01AI047938 · NIAID · UNIVERSITY OF WASHINGTON · PI ERNST, ROBERT K · 2001 to 2010
$3.4M
Host-Pathogen Interactions in Cystic FibrosisK08HL067903 · NHLBI · UNIVERSITY OF WASHINGTON · PI MOSKOWITZ, SAMUEL M · 2001 to 2005
$628k
NCRR NIH HHS M01 RR000037NCRR NIH HHS M01RR-00037NHLBI NIH HHS K08 HL067903NHLBI NIH HHS K08HL67903NIAID NIH HHS AI047938NIAID NIH HHS R01 AI047938PHS HHS K064954
6 · The paper itself

Abstract

Three structural features of lipid A (addition of palmitate [C16 fatty acid], addition of aminoarabinose [positively charged amino sugar residue], and retention of 3-hydroxydecanoate [3-OH C10 fatty acid]) were determined for Pseudomonas aeruginosa isolates from patients with cystic fibrosis (CF; n=86), from the environment (n=13), and from patients with other conditions (n=14). Among P. aeruginosa CF isolates, 100% had lipid A with palmitate, 24.6% with aminoarabinose, and 33.3% retained 3-hydroxydecanoate. None of the isolates from the environment or from patients with other conditions displayed these modifications. These results indicate that unique lipid A modifications occur in clinical P. aeruginosa CF isolates.

Indexed as

ArabinoseChildChild, PreschoolChronic DiseaseCystic FibrosisDecanoic AcidsHumansInfantLipid ALung DiseasesPalmitatesPrevalencePseudomonas aeruginosaPseudomonas InfectionsaminoarabinoseArabinoseDecanoic AcidsLipid AmyrmicacinPalmitates

Identifiers

PMID17763333
PMCPMC2723782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.