ArticleJournal of applied physiology (Bethesda, Md. : 1985)2007
Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Pooled it
- Trial
- Inter-individual variability in the adaptation of human muscle specific tension to progressive resistance training.European journal of applied physiology · 2010Trial
- Human skeletal muscle-specific hypertrophy with exercise training and aging: a comprehensive review.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
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- Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management-A State-of-the-Art Narrative Review.International journal of molecular sciences · 2024Review
- Association of the rs3039851 Insertion/Deletion in the GeneBiomedicines · 2023Article
- An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training-induced muscle fiber hypertrophy in younger men.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Association of regular aerobic exercises and neuromuscular junction variants with incidence of frailty: an analysis of the Chinese Longitudinal Health and Longevity Survey.Journal of cachexia, sarcopenia and muscle · 2021Article
- The Effect of Exercise on Glucoregulatory Hormones: A Countermeasure to Human Aging: Insights from a Comprehensive Review of the Literature.International journal of environmental research and public health · 2019Review
- VCAM-1 upregulation accompanies muscle remodeling following resistance-type exercise in Snell dwarf (Pit1Aging cell · 2018Article
- Dengue virus causes changes of MicroRNA-genes regulatory network revealing potential targets for antiviral drugs.BMC systems biology · 2018Article
- Analysis of cytosine-adenine repeats in P1 promoter region of IGF-1 gene in peripheral blood cells and cervical tissue samples of females with cervical intraepithelial lesions and squamous cervical cancer.Molecular medicine reports · 2015Article
- Does insulin-like growth factor 1 genotype influence muscle power response to strength training in older men and women?European journal of applied physiology · 2012Article
- Integration of immunity with physical and cognitive function in definitions of successful aging.Aging and disease · 2012Article
- A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme.PloS one · 2012Article
- Molecular genetic studies of gene identification for sarcopenia.Human genetics · 2012Review
- A polymorphism near IGF1 is associated with body composition and muscle function in women from the Health, Aging, and Body Composition Study.European journal of applied physiology · 2010Article
- Are calcineurin genes associated with endurance phenotype traits?European journal of applied physiology · 2010Article
- CNTF 1357 G -> A polymorphism and the muscle strength response to resistance training.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
To examine the influence of insulin-like growth factor (IGF) pathway gene polymorphisms on muscle mass and strength responses to strength training (ST), we studied 128 White and Black men and women before and after a 10-wk single-leg knee extension ST program. One-repetition maximum strength, muscle volume (MV) via computed tomography, and muscle quality (MQ) were assessed at baseline and after 10 wk of ST. There was a significant combined IGF1 cytosine adenine (CA) repeat gene effect, which included both the IGF1 CA repeat main effect and IGF1 CA repeat x PPP3R1 insertion-deletion (I/D) gene x gene interaction effect, on the changes in strength (P < 0.01) and MQ (P < 0.05) with ST. There was a trend for a significant gene x gene interaction between IGF1 CA repeat and PPP3R1 I/D for changes in strength (P = 0.07) and MQ (P = 0.06) with ST. The influence of the PPP3R1 A-202C gene polymorphism on change in MV with ST approached significance (P = 0.06). The IGF1 CA repeat polymorphism had a significant influence on the change in strength and MV combined with ST (P < 0.05), whereas the influence of the PPP3R1 I/D polymorphism approached significance (P = 0.08). There were no associations between the IGFBP3 A-202C gene polymorphism and the muscle phenotypic responses to ST. These data suggest that two of the three IGF pathway gene polymorphisms identified in this study influence muscle phenotypic responses to ST in both black and white older men and women.
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Registered trials
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