ArticleAmerican journal of respiratory and critical care medicine2007
4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia.
Article in American journal of respiratory and critical care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- No Association of SERPINE1 -675 Polymorphism With Sepsis Susceptibility: A Meta-Analysis.Medicine · 2015Pooled it
- Plasminogen activator inhibitor-1 and susceptibility to lung cancer: a population genetics perspective.Genetic testing and molecular biomarkers · 2014Trial
- Association betweenInternational journal of molecular sciences · 2023Article
- Risk of Post-Myocardial Infarction Pneumonia with Proton Pump Inhibitors, H2 Receptor Antagonists and Mucoprotective Agents: A Retrospective Nationwide Cohort Study.Journal of personalized medicine · 2022Article
- CYP1A1, GCLC, AGT, AGTR1 gene-gene interactions in community-acquired pneumonia pulmonary complications.Molecular biology reports · 2013Article
- Modifiable risk factors for pneumonia requiring hospitalization of community-dwelling older adults: the Health, Aging, and Body Composition Study.Journal of the American Geriatrics Society · 2013Article
- The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012Article
- A Bayesian hierarchical model for detecting haplotype-haplotype and haplotype-environment interactions in genetic association studies.Human heredity · 2011Article
- 4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study.Critical care (London, England) · 2010Article
- Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia.Critical care (London, England) · 2010Review
- Ecogenomics of respiratory diseases of public health significance.Annual review of public health · 2010Review
- 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia.Anesthesiology · 2009Article
- Comparison of statistical methods for estimating genetic admixture in a lung cancer study of African Americans and Latinos.American journal of epidemiology · 2008Article
- The role of biomarkers in community-acquired pneumonia: predicting mortality and response to adjunctive therapy.Critical care (London, England) · 2008Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
rationalePlasminogen activator inhibitor (PAI)-1 inhibits urokinase and tissue plasminogen activator, required for host response to infection. Whether variation within the PAI-1 gene is associated with increased susceptibility to infection is unknown.
objectivesTo ascertain the role of the 4G/5G polymorphism and other genetic variants within the PAI-1 gene. We hypothesized that variants associated with increased PAI-1 expression would be associated with an increased occurrence of community-acquired pneumonia (CAP).
methodsLongitudinal analysis (>12 yr) of the Health, Aging, and Body Composition cohort, aged 65-74 years at start of analysis. MEASUREMENTS AND MAIN
resultsWe genotyped the 4G/5G PAI-1 polymorphism and six additional single nucleotide polymorphisms. Of the 3,075 subjects, 272 (8.8%) had at least one hospitalization for CAP. Among whites, variants at the PAI4G,5G, PAI2846, and PAI7343 sites had higher risk of CAP (P = 0.018, 0.021, and 0.021, respectively). At these sites, variants associated with higher PAI-1 expression were associated with increased CAP susceptibility. Compared with the 5G/5G genotypes at PAI4G,5G site, the 4G/4G and 4G/5G genotypes were associated with a 1.98-fold increased risk of CAP (95% confidence interval, 1.2-3.2; P = 0.006). In whole blood stimulation assay, subjects with a 4G allele had 3.3- and 1.9-fold increased PAI-1 expression (P = 0.043 and 0.034, respectively). In haplotype analysis, the 4G/G/C/A haplotype at the PAI4G,5G, PAI2846, PAI4588, and PAI7343 single nucleotide polymorphisms was associated with higher CAP susceptibility, whereas the 5G/G/C/A haplotype was associated with lower CAP susceptibility. No associations were seen among blacks.
conclusionsGenotypes associated with increased expression of PAI-1 were associated with increased susceptibility to CAP in elderly whites.
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