ArticleBMC genomics2007
Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies.
Article in BMC genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Refining the genetic risk of breast cancer with rare haplotypes and pattern mining.Life science alliance · 2023Article
- Article
- Novel Locus for Paroxysmal Kinesigenic Dyskinesia Mapped to Chromosome 3q28-29.Scientific reports · 2016Article
- Association between Programmed Cell Death 6 Interacting Protein Insertion/Deletion Polymorphism and the Risk of Breast Cancer in a Sample of Iranian Population.Disease markers · 2015Article
- Pairwise shared genomic segment analysis in three Utah high-risk breast cancer pedigrees.BMC genomics · 2012Article
- The application of nonsense-mediated mRNA decay inhibition to the identification of breast cancer susceptibility genes.BMC cancer · 2012Article
- Genome-wide linkage analysis of QTL for growth and body composition employing the PorcineSNP60 BeadChip.BMC genetics · 2012Article
- A genome-wide linkage study of mammographic density, a risk factor for breast cancer.Breast cancer research : BCR · 2011Article
- Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer.Trends in genetics : TIG · 2010Review
- Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families.Breast cancer research : BCR · 2010Article
- Genome-wide linkage scan reveals three putative breast-cancer-susceptibility loci.American journal of human genetics · 2009Article
- Racial disparity in breast cancer and functional germ line mutation in galectin-3 (rs4644): a pilot study.Cancer research · 2008Article
- No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p.BMC medical genetics · 2008Article
- Stemming the tide of cancer for BRCA1/2 mutation carriers.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2008Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe recent development of new high-throughput technologies for SNP genotyping has opened the possibility of taking a genome-wide linkage approach to the search for new candidate genes involved in heredity diseases. The two major breast cancer susceptibility genes BRCA1 and BRCA2 are involved in 30% of hereditary breast cancer cases, but the discovery of additional breast cancer predisposition genes for the non-BRCA1/2 breast cancer families has so far been unsuccessful.
resultsIn order to evaluate the power improvement provided by using SNP markers in a real situation, we have performed a whole genome screen of 19 non-BRCA1/2 breast cancer families using 4720 genomewide SNPs with Illumina technology (Illumina's Linkage III Panel), with an average distance of 615 Kb/SNP. We identified six regions on chromosomes 2, 3, 4, 7, 11 and 14 as candidates to contain genes involved in breast cancer susceptibility, and additional fine mapping genotyping using microsatellite markers around linkage peaks confirmed five of them, excluding the region on chromosome 3. These results were consistent in analyses that excluded SNPs in high linkage disequilibrium. The results were compared with those obtained previously using a 10 cM microsatellite scan (STR-GWS) and we found lower or not significant linkage signals with STR-GWS data compared to SNP data in all cases.
conclusionOur results show the power increase that SNPs can supply in linkage studies.
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