ArticleBMC developmental biology2007
Inhibition of primordial germ cell proliferation by the medaka male determining gene Dmrt I bY.
Article in BMC developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Genome-wide investigation of the dmrt gene family reveals new insight into the gonad development in Plectropomus leopardus: dmrt2a regulate the development of oocytes.Biology of sex differences · 2025Article
- In-depth investigation of genome to refine QTL positions for spontaneous sex-reversal in XX rainbow trout.PloS one · 2025Article
- Article
- Insights into Early Ontogenesis ofAnimals : an open access journal from MDPI · 2023Article
- Germline stem cells in human.Signal transduction and targeted therapy · 2022Review
- Sexual development dysgenesis in interspecific hybrids of Medaka fish.Scientific reports · 2022Article
- A novel evolutionary conserved mechanism of RNA stability regulates synexpression of primordial germ cell-specific genes prior to the sex-determination stage in medaka.PLoS biology · 2019Article
- Characterization of a male specific region containing a candidate sex determining gene in Atlantic cod.Scientific reports · 2019Article
- Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements.BMC biology · 2018Article
- Retinoic acid and meiosis induction in adult versus embryonic gonads of medaka.Scientific reports · 2016Article
- Autosomal gsdf acts as a male sex initiator in the fish medaka.Scientific reports · 2016Article
- Dmy initiates masculinity by altering Gsdf/Sox9a2/Rspo1 expression in medaka (Oryzias latipes).Scientific reports · 2016Article
- Gene expression analysis at the onset of sex differentiation in turbot (Scophthalmus maximus).BMC genomics · 2015Article
- Defective autophagy through epg5 mutation results in failure to reduce germ plasm and mitochondria.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Plasticity of gene-regulatory networks controlling sex determination: of masters, slaves, usual suspects, newcomers, and usurpators.EMBO reports · 2015Review
- Expanding roles for the evolutionarily conserved Dmrt sex transcriptional regulators during embryogenesis.Cellular and molecular life sciences : CMLS · 2013Review
- Divergent expression regulation of gonad development genes in medaka shows incomplete conservation of the downstream regulatory network of vertebrate sex determination.Molecular biology and evolution · 2013Article
- Article
- Dmrt genes in the development and evolution of sexual dimorphism.Trends in genetics : TIG · 2012Review
- Transcriptional rewiring of the sex determining dmrt1 gene duplicate by transposable elements.PLoS genetics · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDmrt I is a highly conserved gene involved in the determination and early differentiation phase of the primordial gonad in vertebrates. In the fish medaka dmrt I bY, a functional duplicate of the autosomal dmrt I a gene on the Y-chromosome, has been shown to be the master regulator of male gonadal development, comparable to Sry in mammals. In males mRNA and protein expression was observed before morphological sex differentiation in the somatic cells surrounding primordial germ cells (PGCs) of the gonadal anlage and later on exclusively in Sertoli cells. This suggested a role for dmrt I bY during male gonad and germ cell development.
resultsWe provide functional evidence that expression of dmrt I bY leads to negative regulation of PGC proliferation. Flow cytometric measurements revealed a G2 arrest of dmrt I bY expressing cells. Interestingly, also non-transfected cells displayed a significantly lower fraction of proliferating cells, pointing to a possible non-cell autonomous action of dmrt I bY. Injection of antisense morpholinos led to an increase of PGCs in genetically male embryos due to loss of proliferation inhibition.
conclusionIn medaka, dmrt I bY mediates a mitotic arrest of PGCs in males prior to testes differentiation at the sex determination stage. This occurs possibly via a cross-talk of Sertoli cells and PGCs.
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