Evidence map›Paper›PMID 17760840›Full record

ArticleJournal of cellular and molecular medicine

Caveolin and MAP kinase interaction in angiotensin II preconditioning of the myocardium.

Manika Das, Samarjit Das, Dipak K Das

RetractedOpen access · bronzeAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Myocardial AKT: the omnipresent nexus.Physiological reviews · 2011
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Lipid raft in cardiac health and disease.Current cardiology reviews · 2009
    Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Manika DasCardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030, USA. ddas@neuron.uchc.edu
Samarjit Das
Dipak K Das
University of Connecticut · US

Funding

PHOSPHOLIPIDS IN MYOCARDIAL REPERFUSION INJURYR01HL034360 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DAS, DIPAK K · 1987 to 2009
$2.8M
MYOCARDIAL PRESERVATION DURING ISCHEMIC ARRESTR01HL022559 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DAS, DIPAK K · 1985 to 2008
$2.7M
SUPEROXIDE RADICALS IN REPERFUSION INJURYR01HL033889 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DAS, DIPAK K · 1986 to 1988
–
NHLBI NIH HHS HL 22559NHLBI NIH HHS HL 33889NHLBI NIH HHS HL 34360NHLBI NIH HHS R01 HL022559NHLBI NIH HHS R01 HL034360
6 · The paper itself

Abstract

Angiotensin II (Ang II) has been found to exert preconditioning (PC)-like effect in mammalian hearts. The present investigation reported for the first time a unique mitogen activated protein (MAP) kinase signalling in Ang II PC of the heart involving lipid rafts, which generated a survival signal by differentially associating MAP kinases with caveolin. A group of rat hearts was treated with Ang II in the absence or presence of NADPH oxidase inhibitor, apocynin or a cell permeable reactive oxygen species (ROS) scavenger, N-acetyl-cysteine (NAC). Ang II pre-treatment improved post-ischaemic ventricular recovery, myocardial infraction and decreased the number of cardiomyocyte apoptosis indicating PC effect of Ang II. Both apocynin and NAC abolished the PC ability of Ang II. In Ang II treated heart, there was a decreased association of p38MAPKbeta & extracellular-signal regulated kinase (ERK) 1/ 2 (anti-death signalling component) with caveolin while there was an increased association of p38MAPKalpha & Jun N-terminal kinase (JNK) (death signalling component) indicating reduced amount of death signal components and increased amount of anti-death signalling components being available to the Ang II treated heart to generate a survival signal, which was reversed with NAC or apocynin. The survival signal was also demonstrated by increased phosphorylation of serine/threonine-protein kinase B (AKT) and enhanced induction of expression of Bcl-2 during Ang II PC and its reversal with NAC & apocynin treated heart.

Indexed as

Ischemic Preconditioning, MyocardialAcetophenonesAcetylcysteineAngiotensin IIAnimalsApoptosisCaveolinsIn Vitro TechniquesMitogen-Activated Protein KinasesMyocytes, CardiacPhosphoproteinsProtein BindingProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-bcl-2RatsAcetophenonesacetovanilloneAcetylcysteineAngiotensin IICaveolinsMitogen-Activated Protein KinasesPhosphoproteinsProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-bcl-2

Identifiers

PMID17760840
PMCPMC3823257
OpenAlexW2019667072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.