ReviewJournal of cellular and molecular medicine
Programming the genome in embryonic and somatic stem cells.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review.International journal of environmental research and public health · 2021Review
- The brain-placental axis: Therapeutic and pharmacological relevancy to pregnancy.Pharmacological research · 2019Review
- Insulin-like growth factors and their potential role in cardiac epigenetics.Journal of cellular and molecular medicine · 2016Review
- Neonatal tumours.Pediatric surgery international · 2013Review
- Article
- Epigenetic programming and risk: the birthplace of cardiovascular disease?Stem cell reviews and reports · 2013Review
- Gene promoter methylation is associated with lung function in the elderly: the Normative Aging Study.Epigenetics · 2012Article
- Expression patterns and function of chromatin protein HMGB2 during mesenchymal stem cell differentiation.The Journal of biological chemistry · 2011Article
- ROR2 Promoter Methylation Change in Osteoblastic Differentiation of Mesenchymal Stem Cells.Cell journal · 2011Article
- Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5.Transcription · 2010Article
- The generation of hepatocytes from mesenchymal stem cells and engraftment into murine liver.Nature protocols · 2010Article
- A comparative approach to the principal mechanisms of different memory systems.Die Naturwissenschaften · 2009Review
- Prognostic role of global DNA-methylation and histone acetylation in pT1a clear cell renal carcinoma in partial nephrectomy specimens.Journal of cellular and molecular medicine · 2009Article
- The pursuit of ES cell lines of domesticated ungulates.Stem cell reviews · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In opposition to terminally differentiated cells, stem cells can self-renew and give rise to multiple cell types. Embryonic stem cells retain the ability of the inner cell mass of blastocysts to differentiate into all cell types of the body and have acquired in culture unlimited self-renewal capacity. Somatic stem cells are found in many adult tissues, have an extensive but finite lifespan and can differentiate into a more restricted array of cell types. A growing body of evidence indicates that multi-lineage differentiation ability of stem cells can be defined by the potential for expression of lineage-specification genes. Gene expression, or as emphasized here, potential for gene expression, is largely controlled by epigenetic modifications of DNA and chromatin on genomic regulatory and coding regions. These modifications modulate chromatin organization not only on specific genes but also at the level of the whole nucleus; they can also affect timing of DNA replication. This review highlights how mechanisms by which genes are poised for transcription in undifferentiated stem cells are being uncovered through primarily the mapping of DNA methylation, histone modifications and transcription factor binding throughout the genome. The combinatorial association of epigenetic marks on developmentally regulated and lineage-specifying genes in undifferentiated cells seems to define a pluripotent state.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.