ArticleJournal of clinical microbiology1991
Protein X of Streptococcus agalactiae induces opsonic antibodies in cows.
Article in Journal of clinical microbiology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Article
- Development of specific and rapid detection of bacterial pathogens in dairy products by PCR.Folia microbiologica · 2006Article
- Surface proteins of Streptococcus agalactiae and related proteins in other bacterial pathogens.Clinical microbiology reviews · 2005Review
- Identification of major outer surface proteins of Streptococcus agalactiae.Infection and immunity · 2002Article
- Deposition of complement components on Streptococcus agalactiae in bovine milk in the absence of inflammation.Infection and immunity · 1995Article
- Activation of the classical pathway of complement by binding of bovine lactoferrin to unencapsulated Streptococcus agalactiae.Immunology · 1993Article
- Opsonization of Streptococcus agalactiae of bovine origin by complement and antibodies against group B polysaccharide.Infection and immunity · 1992Article
- Isotype antibody response in cows to Streptococcus agalactiae group B polysaccharide-ovalbumin conjugate.Journal of clinical microbiology · 1992Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein X of Streptococcus agalactiae is a surface protein frequently associated with strains isolated from cases of mastitis of dairy cows. By immunizing cows with purified protein X, we obtained an antibody response which was restricted to X-bearing strains of S. agalactiae in a whole-cell enzyme-linked immunosorbent assay. This response resulted in an increase in the opsonic activity of serum for strains bearing protein X, as assessed through the augmentation of the chemiluminescence response of phagocytosing polymorphonuclear cells and through an increased ingestion of bacteria, although the proportion of ingested bacteria which were killed (about 60%) remained unchanged. Protein X behaved as a target of opsonins and, as such, could be a protective antigen worth incorporating in a vaccine against S. agalactiae mastitis.
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Registered trials
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