ArticleWorld journal of gastroenterology2007
Matrix metalloproteinase-9-1562C>T polymorphism may increase the risk of lymphatic metastasis of colorectal cancer.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Association between promoters polymorphisms of matrix metalloproteinases and risk of digestive cancers: a meta-analysis.Journal of cancer research and clinical oncology · 2013Pooled it
- Update analysis of studies on the MMP-9 -1562 C>T polymorphism and cancer risk.Molecular biology reports · 2012Pooled it
- Pooled it
- Meta-analysis of associations between polymorphisms in the promoter regions of matrix metalloproteinases and the risk of colorectal cancer.International journal of colorectal disease · 2011Pooled it
- Single Nucleotide Polymorphism in SMAD7 and CHI3L1 and Colorectal Cancer Risk.Mediators of inflammation · 2018Review
- Does MMP-9 Gene Polymorphism Play a Role in Pituitary Adenoma Development?Disease markers · 2017Article
- Single Nucleotide Polymorphisms as Prognostic and Predictive Factors of Adjuvant Chemotherapy in Colorectal Cancer of Stages I and II.Gastroenterology research and practice · 2016Review
- Correlation between the -1562C/T polymorphism in the matrix metalloproteinase-9 gene and hemorrhagic transformation of ischemic stroke.Experimental and therapeutic medicine · 2015Article
- Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants.World journal of biological chemistry · 2014Review
- Genetic polymorphisms of matrix metalloproteinases and clinical outcomes in colorectal cancer patients.International journal of medical sciences · 2013Article
- Associations of non-metastatic cells 1 gene polymorphisms with lymph node metastasis risk of gastric cancer in Northern Chinese population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- The behavior of matrix metalloproteinases and their inhibitors in colorectal cancer.International journal of molecular sciences · 2012Review
- Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers.International journal of cancer · 2012Article
- Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer.World journal of gastrointestinal oncology · 2011Article
- Functional polymorphisms of matrix metallopeptidase-9 and risk of coronary artery disease in a Chinese population.Molecular biology reports · 2010Article
- Matrix Metalloproteinase-9 (MMP9)-A Mediating Enzyme in Cardiovascular Disease, Cancer, and Neuropsychiatric Disorders.Cardiovascular psychiatry and neurology · 2009Article
- Prognostic significance of matrix metalloproteinase-9 (MMP-9) in stage II colorectal carcinoma.Journal of gastrointestinal cancer · 2009Article
- Impacts of Matrix Metalloproteinase 9 Genotypes on Renal Cell Carcinoma.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore the role of the matrix metalloproteinase-9 (MMP-9) polymorphism in colorectal cancer (CRC) in a northeast Chinese population.
methodsGenotyping of MMP-9-1562C>T and 279R>Q polymorphisms was carried out on blood samples from 137 colorectal cancer patients and 199 controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to calculate adjusted odds ratios (OR) and 95% confidence intervals (95% CI).
resultsThe distribution of MMP-9 -1562C>T and 279 R>Q genotype was not significantly associated with the risk of CRC. However, the risk of llymph node metastasis of CRC was increased in patients with the -1562T allele (OR = 2.601; 95% CI = 1.160-5.835; P = 0.022). The frequency of MMP-9 279RR + RQ genotype was higher than the QQ genotype among CRC patients younger than sixty years old (OR = 0.102; 95% CI = 0.013-0.812; P = 0.012).
conclusionOur results indicated that the MMP-9-1562C>T polymorphism affects lymph node metastasis of CRC. In addition, the MMP-9 279R allele may lead to a younger age of onset of colorectal cancer.
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