ArticleThe European physical journal. E, Soft matter2007
Solution of the Poisson-Nernst-Planck equations in the cell-substrate interface.
Article in The European physical journal. E, Soft matter, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Comparative analysis of system identification techniques for nonlinear modeling of the neuron-microelectrode junction.Journal of computational and theoretical nanoscience · 2013Article
- Label-free electrophysiological cytometry for stem cell-derived cardiomyocyte clusters.Lab on a chip · 2013Article
- An optimization-based study of equivalent circuit models for representing recordings at the neuron-electrode interface.IEEE transactions on bio-medical engineering · 2012Article
- Transmission electron microscopy study of the cell-sensor interface.Journal of the Royal Society, Interface · 2008Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrogenic cells are able to generate electrical signals which can be measured by various invasive electrophysiological methods such as patch-clamp or sharp microelectrode recordings. Growing cells on the surfaces of e.g. metal microelectrodes or field-effect transistors allows the recording of an extracellular component of these signals. For an understanding of such extracellular signals it is mandatory to get detailed topographical as well as electrical information about the cell-sensor interface. In a first approximation, this interface can be described by a flat disk between cell membrane and sensor surface. For a correct description of the signals, the electrodiffusion of ions in this interface is modeled by using the stationary Poisson-Nernst-Planck equations. We solve the equations analytically, and derive expressions for the potential, the ionic charge densities, and the seal resistance. The results provide a method for determining the distance h between sensor surface and cell membrane. For human embryonic kidney cells, we receive h approximately 70 nm. Comparison with literature shows good agreement.
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