ArticleGenes and immunity2007
Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis.
Article in Genes and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- KLF13 promotes SLE pathogenesis by modifying chromatin accessibility of key proinflammatory cytokine genes.Communications biology · 2024Article
- Modelling clinical systemic lupus erythematosus: similarities, differences and success stories.Rheumatology (Oxford, England) · 2017Review
- Molecular and Immunological Basis of Tubulo-Interstitial Injury in Lupus Nephritis: a Comprehensive Review.Clinical reviews in allergy & immunology · 2017Review
- Autoantigen Microarray for High-throughput Autoantibody Profiling in Systemic Lupus Erythematosus.Genomics, proteomics & bioinformatics · 2015Review
- The BAFF/APRIL system in SLE pathogenesis.Nature reviews. Rheumatology · 2014Review
- B cell-specific loss of Lyn kinase leads to autoimmunity.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Identical twins:one with anti-glomerular basement membrane glomerulonephritis,the other with systemic lupus erythematosus.BMC nephrology · 2013Article
- Immunization with 60 kD Ro peptide produces different stages of preclinical autoimmunity in a Sjögren's syndrome model among multiple strains of inbred mice.Clinical and experimental immunology · 2013Article
- Prolactin rescues and primes autoreactive B cells directly and indirectly through dendritic cells in B6.Sle3 mice.Clinical and experimental immunology · 2013Article
- TLR7 and TLR9 in SLE: when sensing self goes wrong.Immunologic research · 2012Review
- Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation.The Journal of experimental medicine · 2012Article
- Role of MHC-linked susceptibility genes in the pathogenesis of human and murine lupus.Clinical & developmental immunology · 2012Review
- The lupus phenotype in B6.NZBc1 congenic mice reflects interactions between multiple susceptibility loci and a suppressor locus.Genes and immunity · 2011Article
- Macrophages from lupus-prone MRL mice have a conditional signaling abnormality that leads to dysregulated expression of numerous genes.Immunogenetics · 2011Article
- Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.Genes and immunity · 2010Article
- Genetics of SLE: evidence from mouse models.Nature reviews. Rheumatology · 2010Review
- An NZW-derived interval on chromosome 7 moderates sialadenitis, but not insulitis in congenic nonobese diabetic mice.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- The lupus-susceptibility gene kallikrein downmodulates antibody-mediated glomerulonephritis.Genes and immunity · 2009Article
- Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans.The Journal of clinical investigation · 2009Article
- Multiple roles of Lyn kinase in myeloid cell signaling and function.Immunological reviews · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Genetic analyses of the lupus-prone NZM2410 mouse have identified multiple susceptibility loci on chromosome 7, termed Sle3 and Sle5. Both of these loci were contained within a large congenic interval, originally termed as Sle3 that strongly impacts a variety of myeloid and T-cell phenotypes and mediates fatal lupus nephritis when combined with Sle1. We have now produced two subcongenic strains, B6.Sle3 and B6.Sle5, carrying the Sle3 and Sle5 intervals separately and characterized their phenotypes as monocongenic strains and individually in combination with Sle1. Neither B6.Sle3 nor B6.Sle5 monocongenic strain develop severe autoimmunity; however, both of these intervals cause the development of severe glomerulonephritis when combined with Sle1. Thus, B6.Sle1Sle3 and B6.Sle1Sle5 exhibit splenomegaly, expansion of activated B and CD4+ T-cell populations and high levels of IgG and IgM autoantibodies targeting multiple nuclear antigens, intact glomeruli and various other autoantigens. In addition, B6.Sle1Sle3 mice also produced higher levels of IgA antinuclear autoantibodies, which were implicated in the development of IgA nephropathy. Our results indicate that Sle3 and Sle5 can independently complement with Sle1, through shared and unique mechanisms, to mediate the development of severe autoimmunity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.