ArticleJournal of clinical microbiology2007
Clonal expansion and microevolution of quinolone-resistant Salmonella enterica serotype typhi in Vietnam from 1996 to 2004.
Article in Journal of clinical microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
- Trial
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- Determination of Phylogroups, Pathotypes and Antibiotic Resistance Profiles ofPathogens (Basel, Switzerland) · 2025Article
- Predominance of multidrug-resistant Salmonella Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar.PLoS neglected tropical diseases · 2024Article
- Whole Genome Sequencing Analysis ofMicroorganisms · 2021Review
- A Single Nucleotide Polymorphism inFrontiers in microbiology · 2021Article
- The clinical and microbiological characteristics of enteric fever in Cambodia, 2008-2015.PLoS neglected tropical diseases · 2017Article
- Emergence of Resistance Mutations inOpen forum infectious diseases · 2017Article
- Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events.Nature genetics · 2015Article
- Evidence for clonal expansion after antibiotic selection pressure: pneumococcal multilocus sequence types before and after mass azithromycin treatments.The Journal of infectious diseases · 2015Article
- MinION nanopore sequencing identifies the position and structure of a bacterial antibiotic resistance island.Nature biotechnology · 2015Article
- Antimicrobial resistance in Salmonella enterica Serovar Typhi isolates from Bangladesh, Indonesia, Taiwan, and Vietnam.Antimicrobial agents and chemotherapy · 2014Article
- Article
- Lack of efflux mediated quinolone resistance in Salmonella enterica serovars Typhi and Paratyphi A.Frontiers in microbiology · 2014Article
- Antibiotic use and resistance in emerging economies: a situation analysis for Viet Nam.BMC public health · 2013Article
- Revised Ciprofloxacin Breakpoints for Salmonella: Is it Time to Write an Obituary?Journal of clinical and diagnostic research : JCDR · 2013Article
- Salmonella enterica serovar Typhi variants in long-term carriers.Journal of clinical microbiology · 2013Article
- Genome sequence and comparative pathogenomics analysis of a Salmonella enterica Serovar Typhi strain associated with a typhoid carrier in Malaysia.Journal of bacteriology · 2012Article
- Insights from the genome sequence of a Salmonella enterica serovar Typhi strain associated with a sporadic case of typhoid fever in Malaysia.Journal of bacteriology · 2012Article
- Molecular typing and resistance analysis of travel-associated Salmonella enterica serotype Typhi.Journal of clinical microbiology · 2012Article
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6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella enterica serotype Typhi clinical isolates (n = 91) resistant to nalidixic acid (Nal(r)) were collected from sporadic cases and minor outbreaks throughout Vietnam between 1996 and 2004. These isolates were typed and compared by four methods: Vi phage typing, PstI ribotyping, XbaI and SpeI pulsed-field gel electrophoresis (PFGE), and single-nucleotide polymorphism (SNP) analysis. The results indicated that 65% of the isolates were not typeable by Vi phage typing. In contrast, the ribotyping and, with more accuracy, the SNP analysis methods indicated that all Nal(r) isolates belonged to a single clone (ribotype 3a, haplotype H58) that was found previously and that largely consisted of plasmid-encoded multidrug-resistant serotype Typhi isolates. PFGE demonstrated the occurrence of microevolution within this clone. We identified two major combined PFGE profiles: X1-S1 and X3-S6. X3-S6 predominated between 1996 and 2002 but was replaced by X1-S1 after 2002. Nevertheless, PFGE, with a Simpson's index of 0.78, was not considered an optimal discriminatory method for investigating typhoid fever outbreaks in Vietnam. The rate of quinolone resistance increased and the rate of multidrug resistance decreased during the study period. From 2002 to 2004, 80.6% of the isolates from South Vietnam were resistant only to Nal. The mechanism of Nal resistance in most of the isolates (94%) was a mutation in the quinolone resistance-determining chromosomal region of gyrA that led to the amino acid substitution Ser83Phe. No plasmid-located qnrA, qnrB, or qnrS was detected.
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