ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
SK channels provide a novel mechanism for the control of frequency tuning in electrosensory neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 73 citations in OpenAlex.
- In vivo neural activity of electrosensory pyramidal cells: Biophysical characterization and phenomenological modeling.PLoS computational biology · 2025Article
- Burst firing optimizes invariant coding of natural communication signals by electrosensory neural populations.iScience · 2025Article
- Receptive field sizes and neuronal encoding bandwidth are constrained by axonal conduction delays.PLoS computational biology · 2023Article
- Descending pathways increase sensory neural response heterogeneity to facilitate decoding and behavior.iScience · 2023Article
- Article
- A Neuro-hormonal Circuit for Paternal Behavior Controlled by a Hypothalamic Network Oscillation.Cell · 2020Article
- Differences in Sodium Channel Densities in the Apical Dendrites of Pyramidal Cells of the Electrosensory Lateral Line Lobe.Frontiers in neural circuits · 2019Article
- SK channel subtypes enable parallel optimized coding of behaviorally relevant stimulus attributes: A review.Channels (Austin, Tex.) · 2017Review
- Synchronous spikes are necessary but not sufficient for a synchrony code in populations of spiking neurons.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Optimized Parallel Coding of Second-Order Stimulus Features by Heterogeneous Neural Populations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Adaptation to second order stimulus features by electrosensory neurons causes ambiguity.Scientific reports · 2016Article
- Temporal decorrelation by SK channels enables efficient neural coding and perception of natural stimuli.Nature communications · 2016Article
- Burst Firing in the Electrosensory System of Gymnotiform Weakly Electric Fish: Mechanisms and Functional Roles.Frontiers in computational neuroscience · 2016Review
- Electrosensory Midbrain Neurons Display Feature Invariant Responses to Natural Communication Stimuli.PLoS computational biology · 2015Article
- The central nervous system transcriptome of the weakly electric brown ghost knifefish (Apteronotus leptorhynchus): de novo assembly, annotation, and proteomics validation.BMC genomics · 2015Article
- Serotonin modulates electrosensory processing and behavior via 5-HT2-like receptors.Neuroscience · 2014Article
- A fast BK-type KCa current acts as a postsynaptic modulator of temporal selectivity for communication signals.Frontiers in cellular neuroscience · 2014Article
- Motion processing across multiple topographic maps in the electrosensory system.Physiological reports · 2014Article
- Neuromodulation of early electrosensory processing in gymnotiform weakly electric fish.The Journal of experimental biology · 2013Review
- Multiplexed temporal coding of electric communication signals in mormyrid fishes.The Journal of experimental biology · 2013Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One important characteristic of sensory input is frequency, with sensory neurons often tuned to narrow stimulus frequency ranges. Although vital for many neural computations, the cellular basis of such frequency tuning remains mostly unknown. In the electrosensory system of Apteronotus leptorhynchus, the primary processing of important environmental and communication signals occurs in pyramidal neurons of the electrosensory lateral line lobe. Spike trains transmitted by these cells can encode low-frequency prey stimuli with bursts of spikes and high-frequency communication signals with single spikes. Here, we demonstrate that the selective expression of SK2 channels in a subset of pyramidal neurons reduces their response to low-frequency stimuli by opposing their burst responses. Apamin block of the SK2 current in this subset of cells induced bursting and increased their response to low-frequency inputs. SK channel expression thus provides an intrinsic mechanism that predisposes a neuron to respond to higher frequencies and thus specific, behaviorally relevant stimuli.
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