Evidence map›Paper›PMID 17728229›Full record

ArticleJournal of virology2007

Myxoma virus expressing human interleukin-12 does not induce myxomatosis in European rabbits.

Marianne M Stanford, John W Barrett, Philippe-Alexandre Gilbert, Richard Bankert, Grant McFadden

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Advances in oncolytic virus therapy for glioma.Recent patents on CNS drug discovery · 2009
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Marianne M StanfordBiotherapeutics Research Group, Robarts Research Institute, Department of Microbiology and Immunology, University of Western Ontario, London, ONT, Canada.
John W Barrett
Philippe-Alexandre Gilbert
Richard Bankert
Grant McFadden
University of Florida · USWestern University · CAUniversity at Buffalo, State University of New York · US

Funding

Re-activating Memory T Cells in the Microenvironment of Human TumorsR01CA131407 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BANKERT, RICHARD B · 2008 to 2017
$3.4M
CD4+ Memory T-Cells in Human Tumor MicroenvironmentR01CA108970 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BANKERT, RICHARD B · 2005 to 2014
$3.0M
NCI NIH HHS CA108970NCI NIH HHS CA131407NCI NIH HHS R01 CA108970NCI NIH HHS R01 CA131407
6 · The paper itself

Abstract

Myxoma virus (MV) is a candidate for oncolytic virotherapy due to its ability to selectively infect and kill tumor cells, yet MV is a species-specific pathogen that causes disease only in European rabbits. To assess the ability of MV to deliver cytokines to tumors, we created an MV (vMyxIL-12) that expresses human interleukin-12 (IL-12). vMyxIL-12 replicates similarly to wild-type MV, and virus-infected cells secrete bioactive IL-12. Yet, vMyxIL-12 does not cause myxomatosis, despite expressing the complete repertoire of MV proteins. Thus, vMyxIL-12 exhibits promise as an oncolytic candidate and is safe in all known vertebrate hosts, including lagomorphs.

Indexed as

Oncolytic VirotherapyAnimalsGenetic VectorsHumansInterleukin-12MiceMyxoma virusNeoplasmsOncolytic VirusesRabbitsInterleukin-12

Identifiers

PMID17728229
PMCPMC2168987
OpenAlexW2105260629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.