ArticleClinical immunology (Orlando, Fla.)2007
CpG oligodeoxynucleotides induce cyclooxygenase-2 in human B lymphocytes: implications for adjuvant activity and antibody production.
Article in Clinical immunology (Orlando, Fla.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Antibody responses after BNT162b2 vaccination in Japanese geriatric intermediate care facilities.Vaccine: X · 2023Article
- Non-steroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection.Journal of virology · 2021Article
- Lipoxin BJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Corticosteroids inhibit anti-IgE activities of specialized proresolving mediators on B cells from asthma patients.JCI insight · 2017Article
- Lipoxin A₄ modulates adaptive immunity by decreasing memory B-cell responses via an ALX/FPR2-dependent mechanism.European journal of immunology · 2014Article
- Reduced T cell-dependent humoral immune response in microsomal prostaglandin E synthase-1 null mice is mediated by nonhematopoietic cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The influence of Cox-2 and bioactive lipids on hematological cancers.Current angiogenesis · 2013Article
- MiR-320a is downregulated in patients with myasthenia gravis and modulates inflammatory cytokines production by targeting mitogen-activated protein kinase 1.Journal of clinical immunology · 2013Article
- Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Prostaglandin E2 synthesizing enzymes in rheumatoid arthritis B cells and the effects of B cell depleting therapy on enzyme expression.PloS one · 2011Article
- Toll-like receptor 9 agonists up-regulates the expression of cyclooxygenase-2 via activation of NF-kappaB in prostate cancer cells.Molecular biology reports · 2010Article
- Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection.Vaccine · 2010Article
- Inhibition of cyclooxygenase-2 impairs the expression of essential plasma cell transcription factors and human B-lymphocyte differentiation.Immunology · 2010Article
- Memory B cells from older people express normal levels of cyclooxygenase-2 and produce higher levels of IL-6 and IL-10 upon in vitro activation.Cellular immunology · 2010Article
- Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Article
- Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells.Cellular immunology · 2009Article
- Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise.Current pharmaceutical design · 2008Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Synthetic CpG oligodeoxynucleotides (ODN), similar to DNA sequences found in certain microorganisms, have shown promise as adjuvants for humans by enhancing immune responses. Since antibodies are often indicators of successful vaccination, it is important to understand how CpG ODNs affect human B cells and influence antibody production. Treatment of human B cells with synthetic CpG ODN sequences increased both steady-state Cox-2 mRNA levels and protein expression. B cell receptor stimulation in concert with CpG ODN treatment induced Cox-2 expression and production of prostaglandin E(2), well above that seen with CpG ODN alone. Importantly, CpG-induced human B cell IgM and IgG production was attenuated by dual Cox-1/Cox-2 inhibitors and Cox-2-selective inhibitors. Our findings support a key role for CpG ODN-induced human B cell Cox-2 in the production of IgM and IgG antibodies, revealing that drugs that attenuate Cox-2 activity have the potential to reduce optimal antibody response to adjuvants/vaccination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.