Trial reportPreventive medicine2007
Eight-year change in body mass index and subsequent risk of cardiovascular disease among healthy non-smoking men.
Trial report in Preventive medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Adult weight gain and the risk of cardiovascular disease: a systematic review and dose-response meta-analysis of prospective cohort studies.European journal of clinical nutrition · 2020Pooled it
- Observational Evidence for Unintentional Weight Loss in All-Cause Mortality and Major Cardiovascular Events: A Systematic Review and Meta-Analysis.Scientific reports · 2018Pooled it
- Changes in fat mass and lean body mass and outcomes in type 2 diabetes mellitus.Internal and emergency medicine · 2022Article
- Influence of changes in body fat on clinical outcomes in a general population: a 12-year follow-up report on the Ansan-Ansung cohort in the Korean Genome Environment Study.Annals of medicine · 2021Article
- Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK.BMC public health · 2021Article
- Incidence of cardiovascular disease and mortality in underweight individuals.Journal of cachexia, sarcopenia and muscle · 2021Article
- Association of Obesity or Weight Change With Coronary Heart Disease Among Young Adults in South Korea.JAMA internal medicine · 2018Article
- Women show a closer association between educational level and hypertension or diabetes mellitus than males: a secondary analysis from the Austrian HIS.BMC public health · 2012Article
- Apolipoprotein ε4 polymorphism does not modify the association between body mass index and high-density lipoprotein cholesterol: a cross-sectional cohort study.Lipids in health and disease · 2011Article
- Changes in BMI over 6 years: the role of demographic and neighborhood characteristics.International journal of obesity (2005) · 2010Article
- A longitudinal and cross-sectional examination of the relationship between reasons for choosing a neighbourhood, physical activity and body mass index.The international journal of behavioral nutrition and physical activity · 2010Article
- Metabolic syndrome and weight gain in adulthood.The journals of gerontology. Series A, Biological sciences and medical sciences · 2010Article
- Risk factors for overweight and obesity, and changes in body mass index of Chinese adults in Shanghai.BMC public health · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveTo determine how change in BMI over 8 years is associated with risk of subsequent cardiovascular disease (CVD) among middle aged men.
methodsProspective cohort study among 13,230 healthy men (aged 51.6+/-8.7 years) in the Physicians' Health Study. BMI was collected at baseline in 1982 and after 8 years, at which time follow-up began. Subsequent CVD events were collected and confirmed through March 31, 2005. Cox proportional hazards models evaluated BMI at 8 years and risk of CVD, 8-year change in BMI and risk of CVD, and whether change in BMI added prognostic information after the consideration of BMI at 8 years.
results1308 major CVD events occurred over 13.5 years. A higher BMI at year 8 was associated with an increased risk of CVD. Compared to a stable BMI (+/-0.5 kg/m(2)), a 0.5-2.0 kg/m(2) increase had a multivariable-adjusted RR of 1.00 (0.86-1.16). A >/=2.0 kg/m(2) increase had a multivariable-adjusted RR of 1.39 (1.16-1.68), however further adjustment for BMI reduced the RR to 1.00 (0.81-1.23). A decrease in BMI had a multivariable RR of 1.23 (1.07-1.42) which was unaffected by adjustment for BMI at 8 years.
conclusionA higher BMI and a rising BMI were both associated with an increased risk of CVD, however an increasing BMI did not add prognostic information once current BMI was considered. In contrast, a declining BMI was associated with an increased risk of CVD independent of current BMI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.