ArticleBMC genomics2007
The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring.
Article in BMC genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Sepsis: Evidence-based pathogenesis and treatment.World journal of critical care medicine · 2021Review
- The role of control region mitochondrial DNA mutations in cardiovascular disease: stroke and myocardial infarction.Scientific reports · 2020Article
- Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine.Clinical science (London, England : 1979) · 2016Review
- Mitochondrial health, the epigenome and healthspan.Clinical science (London, England : 1979) · 2016Review
- Unbiased Mitoproteome Analyses Confirm Non-canonical RNA, Expanded Codon Translations.Computational and structural biotechnology journal · 2016Article
- Chimeric mitochondrial peptides from contiguous regular and swinger RNA.Computational and structural biotechnology journal · 2016Article
- Transmission from centenarians to their offspring of mtDNA heteroplasmy revealed by ultra-deep sequencing.Aging · 2014Article
- The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease.Human genetics · 2014Review
- The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms.BioMed research international · 2014Review
- Exploring the role of genetic variability and lifestyle in oxidative stress response for healthy aging and longevity.International journal of molecular sciences · 2013Review
- Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity.Immunity & ageing : I & A · 2012Article
- Genetics of longevity. data from the studies on Sicilian centenarians.Immunity & ageing : I & A · 2012Article
- Article
- Neutral mitochondrial heteroplasmy and the influence of aging.Human molecular genetics · 2011Article
- Mitochondrial-nuclear epistasis: implications for human aging and longevity.Ageing research reviews · 2011Review
- No relationship found between point heteroplasmy in mitochondrial DNA control region and age range, sex and haplogroup in human hairs.Molecular biology reports · 2011Article
- Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study.PloS one · 2010Article
- Power assessment for genetic association study of human longevity using offspring of long-lived subjects.European journal of epidemiology · 2010Article
- Biomarker Validation for Aging: Lessons from mtDNA Heteroplasmy Analyses in Early Cancer Detection.Biomarker insights · 2009Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies on heteroplasmy occurring in the mitochondrial DNA (mtDNA) control region (CR) in leukocytes of centenarians and younger subjects have shown that the C150T somatic transition is over-represented in centenarians. However, whether the occurrence/accumulation of heteroplasmy is a phenotypic consequence of extreme ageing or a genetically controlled event that may favor longevity is a question that deserves further attention. To clarify this point, we set up a Denaturing High Performance Liquid Chromatography (DHPLC) protocol to quantify mtDNA CR heteroplasmy. We then analyzed heteroplasmy in leukocytes of centenarians (100 subjects), their offspring and nieces/nephews (200 subjects, age-range 65-80 years, median age 70 years), and in leukocytes of 114 control subjects sex- and age-matched with the relatives of centenarians.
resultsThe centenarians and their descendants, despite the different ages, showed similar levels of heteroplasmy which were significantly higher than levels in controls. In addition we found that heteroplasmy levels were significantly correlated in parent-offspring pairs (r = 0.263; p = 0.009), but were independent of mtDNA inherited variability (haplogroup and sequence analyses).
conclusionOur findings suggest that the high degree of heteroplasmy observed in centenarians is genetically controlled, and that such genetic control is independent of mtDNA variability and likely due to the nuclear genome.
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