ReviewDialogues in clinical neuroscience2007
Neuropsychiatric manifestations in CADASIL.
Review in Dialogues in clinical neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- NOTCH3 Mutations in CADASIL: a multicellular perspective on neurodegeneration.Cell communication and signaling : CCS · 2026Review
- Genetic and epigenetic architectures of stroke: Insights from GWAS to precision medicine.Neurochemistry international · 2025Review
- Comorbidity Between Recurrent Major Depressive Disorder and CADASIL: A Case Report With a Brief Review of Published Cases.Clinical case reports · 2025Article
- Article
- CADASIL: A NOTCH3-associated cerebral small vessel disease.Journal of advanced research · 2024Review
- The prevalence of neuropsychiatric symptoms and correlation with MRI findings in CADASIL patients.Annals of clinical and translational neurology · 2024Article
- Investigating the Migraine Cycle over 21 Consecutive Days Using Proton Magnetic Resonance Spectroscopy and Resting-State fMRI: A Pilot Study.Brain sciences · 2022Article
- Cognition, mood and behavior in CADASIL.Cerebral circulation - cognition and behavior · 2022Article
- CADASIL presenting as late-onset mania with anosognosia.Clinical case reports · 2020Article
- A Study of Congenital Protein C Deficiency With Infancy Onset of CADASIL in a Chinese Baby.Journal of pediatric hematology/oncology · 2019Article
- Managing psychotic depression and diagnostic uncertainty in liaison psychiatry.BMJ case reports · 2019Article
- Bipolar II disorder as the initial presentation of CADASIL: an underdiagnosed manifestation.Neuropsychiatric disease and treatment · 2017Article
- Recurrent transient global amnesia as presenting symptoms of CADASIL.Clinical case reports · 2016Article
- A knowledge network for a dynamic taxonomy of psychiatric disease.Dialogues in clinical neuroscience · 2015Review
- Case report: bipolar disorder as the first manifestation of CADASIL.BMC psychiatry · 2014Article
- Detection of early cognitive impairment using AD8 in a young patient with stroke with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome: a case report.American journal of Alzheimer's disease and other dementias · 2014Article
- Migraine and cognitive decline: a topical review.Headache · 2013Review
- Migraine and movement disorders.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2012Review
- Migraine attacks the Basal Ganglia.Molecular pain · 2011Article
- High frequency of exon 10 mutations in the NOTCH3 gene in Italian CADASIL families: phenotypic peculiarities.Journal of neurology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small-artery disease of mid-adulthood caused by mutations of the NOTCH3 gene. The disease is responsible for widespread white-matter lesions associated with lacunar infarctions in various subcortical areas. The disease is responsible for migraine with aura and ischemic strokes, and is associated with various degrees of cognitive impairment and with mood disturbances. CADASIL is considered as a unique model to investigate what is known as "subcortical ischemic vascular dementia." Recent data suggest that the number of lacunar infarctions and severity of cerebral atrophy are the main magnetic resonance imaging markers associated with cognitive and motor disabilities in this disorder. Mood disturbances are reported in 10% to 20% of patients, most often in association with cognitive alterations. Their exact origin remains unknown; the presence of ischemic lesions within the basal ganglia or the frontal white matter may promote the occurrence of these symptoms. Further studies are needed to better understand the relationships between cerebral lesions and both cognitive and psychiatric symptoms in this small-vessel disease of the brain.
Indexed as
Identifiers
17726918PMC3181851W1804764534What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.