ArticlePloS one2007
Molecular characterization of a novel intracellular ADP-ribosyl cyclase.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- CD38-Cyclic ADP-Ribose Signal System in Physiology, Biochemistry, and Pathophysiology.International journal of molecular sciences · 2022Review
- Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos.Developmental biology · 2019Article
- ADP-ribosyl cyclases regulate early development of the sea urchin.Messenger (Los Angeles, Calif. : Print) · 2016Article
- Two-pore channels function in calcium regulation in sea star oocytes and embryos.Development (Cambridge, England) · 2014Article
- Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway.The Journal of biological chemistry · 2012Article
- Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate.Molecular and cellular biochemistry · 2012Article
- The signaling protein CD38 is essential for early embryonic development.The Journal of biological chemistry · 2012Article
- Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation.The Journal of biological chemistry · 2011Article
- Cyclic ADP ribose-dependent Ca2+ release by group I metabotropic glutamate receptors in acutely dissociated rat hippocampal neurons.PloS one · 2011Article
- An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals.The Journal of biological chemistry · 2010Article
- Generation of cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate by CD38 for Ca2+ signaling in interleukin-8-treated lymphokine-activated killer cells.The Journal of biological chemistry · 2010Article
- A single residue in a novel ADP-ribosyl cyclase controls production of the calcium-mobilizing messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate.The Journal of biological chemistry · 2010Article
- The calcium-mobilizing messenger nicotinic acid adenine dinucleotide phosphate participates in sperm activation by mediating the acrosome reaction.The Journal of biological chemistry · 2010Article
- CD38/cADPR/Ca2+ pathway promotes cell proliferation and delays nerve growth factor-induced differentiation in PC12 cells.The Journal of biological chemistry · 2009Article
- cADPR stimulates SERCA activity in Xenopus oocytes.Cell calcium · 2009Article
- Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils.Cell calcium · 2008Article
- Molecular characterization of a novel cell surface ADP-ribosyl cyclase from the sea urchin.Cellular signalling · 2008Article
- Ca(2+) signaling occurs via second messenger release from intraorganelle synthesis sites.Current biology : CB · 2008Article
- Sperm express a Ca2+-regulated NAADP synthase.The Biochemical journal · 2008Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP. Not all ADP-ribosyl cyclases however have been characterized at the molecular level. Moreover, those that have are located predominately at the outer cell surface and thus away from their cytosolic substrates. METHODOLOGY/PRINCIPAL
findingsHere we report the molecular cloning of a novel expanded family of ADP-ribosyl cyclases from the sea urchin, an extensively used model organism for the study of inositol trisphosphate-independent calcium mobilization. We provide evidence that one of the isoforms (SpARC1) is a soluble protein that is targeted exclusively to the endoplasmic reticulum lumen when heterologously expressed. Catalytic activity of the recombinant protein was readily demonstrable in crude cell homogenates, even under conditions where luminal continuity was maintained. CONCLUSIONS/SIGNIFICANCE: Our data reveal a new intracellular location for ADP-ribosyl cyclases and suggest that production of calcium mobilizing messengers may be compartmentalized.
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