ArticlePloS one2007
Simple sequence repeats provide a substrate for phenotypic variation in the Neurospora crassa circadian clock.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 68 citations in OpenAlex.
- Disordered but rhythmic-the role of intrinsic protein disorder in eukaryotic circadian timing.FEBS letters · 2026Review
- Simple sequence repeats and their expansions: role in plant development, environmental response and adaptation.The New phytologist · 2025Review
- A comparative study of population genetic structure reveals patterns consistent with selection at functional microsatellites in common sunflower.Molecular genetics and genomics : MGG · 2022Article
- Circadian-period variation underlies the local adaptation of photoperiodism in the short-day plantiScience · 2022Article
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- A Comparative Analyses of the Complete Mitochondrial Genomes of Fungal Endosymbionts inInternational journal of genomics · 2021Article
- Intrinsic disorder is an essential characteristic of components in the conserved circadian circuit.Cell communication and signaling : CCS · 2020Review
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- Blakeslea trispora Photoreceptors: Identification and Functional Analysis.Applied and environmental microbiology · 2020Article
- No Evidence That Homologs of Key Circadian Clock Genes Direct Circadian Programs of Development or mRNA Abundance inFrontiers in microbiology · 2020Article
- Asexual reproduction and growth rate: independent and plastic life history traits in Neurospora crassa.The ISME journal · 2019Article
- Transgenerational Interaction of Alzheimer's Disease with Schizophrenia through Amyloid Evolvability.Journal of Alzheimer's disease : JAD · 2019Review
- Comparative functional analysis of proteins containing low-complexity predicted amyloid regions.PeerJ · 2018Article
- Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability.Journal of Huntington's disease · 2018Article
- Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins.Nature structural & molecular biology · 2017Article
- RNA biology of disease-associated microsatellite repeat expansions.Acta neuropathologica communications · 2017Review
- Natural Variation of the Circadian Clock in Neurospora.Advances in genetics · 2017Review
- Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates Novel Localization Sequences That Target the Periphery of the Host Erythrocyte.The Journal of biological chemistry · 2016Article
- Aspergillus fumigatus Photobiology Illuminates the Marked Heterogeneity between Isolates.mBio · 2016Article
- A Polynucleotide Repeat Expansion Causing Temperature-Sensitivity Persists in Wild Irish Accessions of Arabidopsis thaliana.Frontiers in plant science · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWHITE COLLAR-1 (WC-1) mediates interactions between the circadian clock and the environment by acting as both a core clock component and as a blue light photoreceptor in Neurospora crassa. Loss of the amino-terminal polyglutamine (NpolyQ) domain in WC-1 results in an arrhythmic circadian clock; this data is consistent with this simple sequence repeat (SSR) being essential for clock function. METHODOLOGY/PRINCIPAL
findingsSince SSRs are often polymorphic in length across natural populations, we reasoned that investigating natural variation of the WC-1 NpolyQ may provide insight into its role in the circadian clock. We observed significant phenotypic variation in the period, phase and temperature compensation of circadian regulated asexual conidiation across 143 N. crassa accessions. In addition to the NpolyQ, we identified two other simple sequence repeats in WC-1. The sizes of all three WC-1 SSRs correlated with polymorphisms in other clock genes, latitude and circadian period length. Furthermore, in a cross between two N. crassa accessions, the WC-1 NpolyQ co-segregated with period length. CONCLUSIONS/SIGNIFICANCE: Natural variation of the WC-1 NpolyQ suggests a mechanism by which period length can be varied and selected for by the local environment that does not deleteriously affect WC-1 activity. Understanding natural variation in the N.crassa circadian clock will facilitate an understanding of how fungi exploit their environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.