ArticleJournal of molecular neuroscience : MN2007
Age alters the ability of substance P to sensitize joint nociceptors in guinea pigs.
Article in Journal of molecular neuroscience : MN, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Radiological changes in shoulder osteoarthritis and pain sensation correlate with patients' age.Journal of orthopaedic surgery and research · 2022Article
- Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene.European journal of pain (London, England) · 2017Article
- Mechanisms and Mediators That Drive Arthritis Pain.Current osteoporosis reports · 2015Review
- Inflammatory nociception responses do not vary with age, but diminish with the pain history.Frontiers in aging neuroscience · 2014Article
- A commentary on modelling osteoarthritis pain in small animals.Osteoarthritis and cartilage · 2013Review
- The impact of age on the hypnotic effects of eszopiclone and zolpidem in the guinea pig.Psychopharmacology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain perception is altered during senescence and it is thought that this could in part be due to changes in peripheral pain sensing processes. The present study examined the effect of substance P (SP) (10(-10)-10(-8) mol; 0.1 mL bolus close intraarterial) on knee joint afferent mechanosensitivity in young (2- to 5-mo-old) and aged (17- to 36-mo-old) Dunkin-Hartley guinea pigs. Single unit electrophysiological recordings were made from knee joint primary afferent nerves in response to normal (nonnoxious) and painful (noxious) rotation of the joint. In young and old animals, local application of SP had a sensitizing effect on joint afferents in response to movements made in the normal working range of the knee. With noxious hyper-rotation of the joint, SP was able to increase afferent firing rate in young but not in old animals. These data demonstrate a lack of SP-mediated sensitization of joint nociceptors during senescence and suggest a peripheral deficiency in joint nociception with respect to age.
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