ArticleGenome research2007
A model of segmental duplication formation in Drosophila melanogaster.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- The Role of Small Segmental Duplications in Generating Identical Isoforms Through Alternative Splicing Sites.Biochemical genetics · 2026Article
- Genomes From 117 Vertebrate Species Reveal Rapidly Evolving Segmental-Duplication Landscapes.Genome biology and evolution · 2026Article
- Genome architecture shapes the evolutionary origins of redundant enhancers in fly and mouse.bioRxiv : the preprint server for biology · 2026Article
- Genomes from 117 vertebrate species reveal rapidly evolving segmental duplication landscapes.bioRxiv : the preprint server for biology · 2025Article
- Divergent evolution of male-determining loci on proto-Y chromosomes of the housefly.Nature communications · 2024Article
- Article
- Comprehensive Analysis of Copy Number Variations on Glycoside Hydrolase 45 Genes among DifferentInternational journal of molecular sciences · 2022Article
- DNA transposons mediate duplications via transposition-independent and -dependent mechanisms in metazoans.Nature communications · 2021Article
- Review
- Multi-faceted analysis provides little evidence for recurrent whole-genome duplications during hexapod evolution.BMC biology · 2020Article
- Small Segmental Duplications in Drosophila-High Rate of Emergence and Elimination.Genome biology and evolution · 2019Article
- The genomic architecture and molecular evolution of ant odorant receptors.Genome research · 2018Article
- Common Bean Subtelomeres Are Hot Spots of Recombination and Favor Resistance Gene Evolution.Frontiers in plant science · 2018Article
- Segmental duplications: evolution and impact among the current Lepidoptera genomes.BMC evolutionary biology · 2017Article
- Expressed Structurally Stable Inverted Duplicates in Mammalian Genomes as Functional Noncoding Elements.Genome biology and evolution · 2017Article
- The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of Homogeneous and Heterogeneous Duplications.PLoS biology · 2016Article
- Article
- Accelerated evolution of schistosome genes coding for proteins located at the host-parasite interface.Genome biology and evolution · 2015Article
- Illumina TruSeq synthetic long-reads empower de novo assembly and resolve complex, highly-repetitive transposable elements.PloS one · 2014Article
- Association of microsatellite pairs with segmental duplications in insect genomes.BMC genomics · 2013Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Segmental duplications (SDs) are low-copy repeats of DNA segments that have long been recognized to be involved in genome organization and evolution. But, to date, the mechanism of their formation remains obscure. We propose a model for SD formation that we name "duplication-dependent strand annealing" (DDSA). This model is a variant of the synthesis-dependent strand annealing (SDSA) model--a double-strand break (DSB) homologous repair model. DSB repair in Drosophila melanogaster genome usually occurs primarily through homologous repair, more preferentially through the SDSA model. The DDSA model predicts that after a DSB, the search for an ectopic homologous region--here a repeat--initiates the repair. As expected by the model, the analysis of SDs detected by a computational analysis of the D. melanogaster genome indicates a high enrichment in transposable elements at SD ends. It shows moreover a preferential location of SDs in heterochromatic regions. The model has the advantage of also predicting specific traces left during synthesis. The observed traces support the DDSA model as one model of formation of SDs in D. melanogaster genome. The analysis of these DDSA signatures suggests moreover a sequestration of the dissociated strand in the repair complex.
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