ArticleProceedings of the National Academy of Sciences of the United States of America2007
A cyclic nucleotide-gated channel is essential for polarized tip growth of pollen.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
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Who cites it
121 citing papers in PubMed.
- CNGCs in Marchantia paleacea uncouple arbuscular mycorrhizal symbiosis and rhizoid development.The New phytologist · 2026Article
- A cyclic nucleotide-gated channel gene HcCNGC11 positively regulates salt stress responses in kenaf (Hibiscus cannabinus L.).Plant molecular biology · 2026Article
- Genome-wide identification, characterization and expression analysis of CNGC Genes in moso bamboo (Phyllostachys edulis).BMC plant biology · 2025Article
- Cryo-EM structures of Arabidopsis CNGC1 and CNGC5 reveal molecular mechanisms underlying gating and calcium selectivity.Nature plants · 2025Article
- Cellular calcium homeostasis and regulation of its dynamic perturbation.Quantitative plant biology · 2025Review
- Genome-wide identification of cyclic nucleotide-gated channel gene family inFrontiers in plant science · 2025Article
- The Role of Female and Male Genes in Regulating Pollen Tube Guidance in Flowering Plants.Genes · 2024Review
- Genome Analysis ofInternational journal of molecular sciences · 2024Article
- Differential phosphorylation of Ca2+-permeable channel CYCLIC NUCLEOTIDE-GATED CHANNEL20 modulates calcium-mediated freezing tolerance in Arabidopsis.The Plant cell · 2024Article
- Osmosensor-mediated control of CaNature · 2024Article
- Distribution of exchangeable CaScientific reports · 2024Article
- CsMLO8/11 are required for full susceptibility of cucumber stem to powdery mildew and interact with CsCRK2 and CsRbohD.Horticulture research · 2024Article
- Article
- Genome-wide identification and expression analysis of the cyclic nucleotide-gated ion channel (CNGC) gene family in Saccharum spontaneum.BMC genomics · 2023Article
- Overexpressing Vitamin C Defective 2 reduces fertility and alters Ca2+ signals in Arabidopsis pollen.Plant physiology · 2023Article
- Identification ofBiology · 2023Article
- The captivating role of calcium in plant-microbe interaction.Frontiers in plant science · 2023Review
- RALF signaling pathway activates MLO calcium channels to maintain pollen tube integrity.Cell research · 2023Article
- The impact of heat stress in plant reproduction.Frontiers in plant science · 2023Review
- Transcriptome analysis reveals the regulation of cyclic nucleotide-gated ion channels in response to exogenous abscisic acid and calcium treatment under drought stress in tomato.Frontiers in genetics · 2023Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Ion signals are critical to regulating polarized growth in many cell types, including pollen in plants and neurons in animals. Genetic evidence presented here indicates that pollen tube growth requires cyclic nucleotide-gated channel (CNGC) 18. CNGCs are nonspecific cation channels found in plants and animals and have well established functions in excitatory signal transduction events in animals. In Arabidopsis, male sterility was observed for two cngc18 null mutations. CNGC18 is expressed primarily in pollen, as indicated from a promoter::GUS (beta-glucuronidase) reporter analysis and expression profiling. The underlying cause of sterility was identified as a defect in pollen tube growth, resulting in tubes that were kinky, short, often thin, and unable to grow into the transmitting tract. Expression of a GFP-tagged CNGC18 in mutant pollen provided complementation and evidence for asymmetric localization of CNGC18 to the plasma membrane at the growing tip, starting at the time of pollen grain germination. Heterologous expression of CNGC18 in Escherichia coli resulted in a time- and concentration-dependent accumulation of more Ca2+. Thus, CNGC18 provides a mechanism to directly transduce a cyclic nucleotide (cNMP) signal into an ion flux that can produce a localized signal capable of regulating the pollen tip-growth machinery. These results identify a CNGC that is essential to an organism's life cycle and raise the possibility that CNGCs have a widespread role in regulating cell-growth dynamics in both plant and animals.
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