ArticleMolecular microbiology2007
Substrate induction of siderophore transport in Bacillus subtilis mediated by a novel one-component regulator.
Article in Molecular microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Bacilli the most important biocontrol agent in Brazilian agriculture: from mechanisms of action to market adoption.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Review
- Integrated functional genomics and safety assessment of plant-growth-promoting Caryophanales from post-maize-cultivation soils.BMC genomics · 2026Article
- Context-dependent siderophore exploitability shapes microbial community structure.The ISME journal · 2026Article
- Organohalide respiration by a Desulforhopalus-dominated community.The ISME journal · 2026Article
- Enhancing multi-season wheat yield through plant growth-promoting rhizobacteria using consortium and individual isolate applications.Folia microbiologica · 2025Article
- The Transcriptomic Response of Cells of the Thermophilic BacteriumInternational journal of molecular sciences · 2024Article
- FoxR is an AraC-like transcriptional regulator of ferrioxamine uptake in Salmonella enterica.Molecular microbiology · 2022Article
- sRNA-controlled iron sparing response in Staphylococci.Nucleic acids research · 2022Article
- Mirubactin C rescues the lethal effect of cell wall biosynthesis mutations inFrontiers in microbiology · 2022Article
- Functional Seasonality of Free-Living and Particle-Associated Prokaryotic Communities in the Coastal Adriatic Sea.Frontiers in microbiology · 2020Article
- Sequential induction of Fur-regulated genes in response to iron limitation inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Specificity of metal sensing: iron and manganese homeostasis in Bacillus subtilis.The Journal of biological chemistry · 2014Review
- Bacillus pumilus reveals a remarkably high resistance to hydrogen peroxide provoked oxidative stress.PloS one · 2014Article
- Global analysis of transcriptional regulators in Staphylococcus aureus.BMC genomics · 2013Article
- Transcription activation by the siderophore sensor Btr is mediated by ligand-dependent stimulation of promoter clearance.Nucleic acids research · 2012Article
- An extracytoplasmic function sigma factor-mediated cell surface signaling system in Pseudomonas syringae pv. tomato DC3000 regulates gene expression in response to heterologous siderophores.Journal of bacteriology · 2011Article
- Staphylococcus aureus transporters Hts, Sir, and Sst capture iron liberated from human transferrin by Staphyloferrin A, Staphyloferrin B, and catecholamine stress hormones, respectively, and contribute to virulence.Infection and immunity · 2011Article
- Characterization of a Bacillus subtilis transporter for petrobactin, an anthrax stealth siderophore.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Direct stimulus perception and transcription activation by a membrane-bound DNA binding protein.Molecular microbiology · 2009Article
- Siderophore-mediated iron acquisition systems in Bacillus cereus: Identification of receptors for anthrax virulence-associated petrobactin .Biochemistry · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
When iron is scarce, Bacillus subtilis expresses genes involved in the synthesis and uptake of the siderophore bacillibactin (BB) and uptake systems to pirate other microbial siderophores. Here, we demonstrate that transcriptional induction of the feuABCybbA operon, encoding the Fe-BB uptake system, is mediated by Btr (formerly YbbB), which is encoded by the immediately upstream gene. Btr contains an AraC-type DNA binding domain fused to a substrate binding protein (SBP) domain related to FeuA, the SBP for Fe-BB uptake. When cells are iron-limited, the Fur-mediated repression of btr is relieved and Btr binds to a conserved direct repeat sequence adjacent to feuA to activate transcription. If BB is present, Btr further activates feuA expression. Btr binds with high affinity to both apo-BB and Fe-BB, and the resulting complex displays a significantly increased efficacy as a transcriptional activator relative to Btr alone. Btr can also activate transcription in response to the structurally similar siderophore enterobactin, although genetic analyses indicate that the two siderophores make distinct interactions with the Btr substrate binding domain. Thus, the FeuABC transporter is optimally expressed under conditions of iron starvation, when Fur-mediated repression is relieved, and in the presence of its cognate substrate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.