ArticleWorld journal of gastroenterology2007
Association of the frequency of peripheral natural killer T cells with nonalcoholic fatty liver disease.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Altered Frequency, Activation, and Clinical Relevance of Circulating Innate and Innate-Like Lymphocytes in Patients With Alcoholic Liver Cirrhosis.Immune network · 2023Article
- Innate immunity and early liver inflammation.Frontiers in immunology · 2023Review
- Bile acid activated receptors: Integrating immune and metabolic regulation in non-alcoholic fatty liver disease.Liver research (Beijing, China) · 2021Review
- The Differential Roles of T Cells in Non-alcoholic Fatty Liver Disease and Obesity.Frontiers in immunology · 2019Review
- Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Parallel Profiles of Inflammatory and Effector Memory T Cells in Visceral Fat and Liver of Obesity-Associated Cancer Patients.Inflammation · 2016Article
- The Immune Landscape in Nonalcoholic Steatohepatitis.Immune network · 2016Review
- IL-17 Axis Driven Inflammation in Non-Alcoholic Fatty Liver Disease Progression.Current drug targets · 2015Review
- Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation.International journal of molecular sciences · 2014Review
- Probiotic antigens stimulate hepatic natural killer T cells.Immunology · 2014Article
- CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH).Seminars in immunopathology · 2014Review
- Immune cells and metabolic dysfunction.Seminars in immunopathology · 2014Review
- Immune and inflammatory pathways in NASH.Hepatology international · 2013Review
- Role of gut microbiota in liver diseases.Hepatology research : the official journal of the Japan Society of Hepatology · 2013Article
- Role of NKT Cells in the Pathogenesis of NAFLD.International journal of hepatology · 2012Article
- Fatty liver is associated with recurrent bacterial infections independent of metabolic syndrome.Digestive diseases and sciences · 2011Article
- The split personality of NKT cells in malignancy, autoimmune and allergic disorders.Immunotherapy · 2011Review
- Intrahepatic natural killer T cell populations are increased in human hepatic steatosis.World journal of gastroenterology · 2011Article
- Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet.Journal of gastroenterology · 2010Article
- Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients.PloS one · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate whether changes in the frequency of peripheral natural killer T (NKT) cells were correlated with liver disease in patients who had metabolic predispositions to nonalcoholic fatty liver disease (NAFLD).
methodsPeripheral blood samples were obtained from 60 Chinese NAFLD patients and 60 age and gender matched healthy controls. The frequency of peripheral NKT cells was detected by flow cytometry. Clinical and laboratory data were collected for further analysis.
resultsNAFLD patients had a lower frequency of peripheral NKT cells than healthy controls (1.21% +/- 0.06% vs 1.62% +/- 0.07%, P < 0.001). Further analysis revealed that the frequency of peripheral NKT cells was negatively correlated with body mass index, waist circumference and serum levels of alanine aminotransferase. Logistic regression analysis revealed that elevated body mass index [hazard ratio (HR): 2.991], aspartate aminotransferase levels (HR: 1.148) and fasting blood sugar (HR: 3.133) increased the risk of NAFLD, whereas an elevated frequency of peripheral NKT cells (HR: 0.107) decreased the risk.
conclusionChanges in the frequency of peripheral NKT cells were correlated with NAFLD and a decreased frequency of peripheral NKT cells was a risk factor for NAFLD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.