ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2008
Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Rebelled epigenome: histone H3S10 phosphorylation and H3S10 kinases in cancer biology and therapy.Clinical epigenetics · 2020Review
- Signaling coupled epigenomic regulation of gene expression.Oncogene · 2017Review
- Interleukin-33/ST2 axis promotes epithelial cell transformation and breast tumorigenesis via upregulation of COT activity.Oncogene · 2015Article
- Article
- Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer.International journal of molecular sciences · 2015Review
- Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges.Frontiers in genetics · 2014Review
- Signal transduction and molecular targets of selected flavonoids.Antioxidants & redox signaling · 2013Review
- miR-31 regulates interleukin 2 and kinase suppressor of ras 2 during T cell activation.Genes and immunity · 2013Article
- Increased histone H3 phosphorylation in neurons in specific brain structures after induction of status epilepticus in mice.PloS one · 2013Article
- Histone H3 phosphorylation - a versatile chromatin modification for different occasions.Biochimie · 2012Review
- 7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4.The Journal of biological chemistry · 2011Article
- Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma.Chinese medicine · 2011Article
- TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth.PloS one · 2011Article
- Tpl2/AP-1 enhances murine gammaherpesvirus 68 lytic replication.Journal of virology · 2010Article
- Tpl2 is a key mediator of arsenite-induced signal transduction.Cancer research · 2009Article
- NF-κB and cancer: a paradigm of Yin-Yang.American journal of cancer researchArticle
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Post-translational modification of histones is critical for gene expression, mitosis, cell growth, apoptosis, and cancer development. Thus, finding protein kinases that are responsible for the phosphorylation of histones at critical sites is considered an important step in understanding the process of histone modification. The serine/threonine kinase Cot is a member of the mitogen-activated protein kinase (MAPK) kinase kinase family. We show here that Cot can phosphorylate histone H3 at Ser-10 in vivo and in vitro, and that the phosphorylation of histone H3 at Ser-10 is required for Cot-induced cell transformation. We found that activated Cot is recruited to the c-fos promoter resulting in increased activator protein-1 (AP-1) transactivation. The formation of the Cot-c-fos promoter complex was also apparent when histone H3 was phosphorylated at Ser-10. Furthermore, the use of dominant negative mutants of histone H3 revealed that Cot was required for phosphorylation of histone H3 at Ser-10 to induce neoplastic cell transformation. These results revealed an important function of Cot as a newly discovered histone H3 kinase. Moreover, the transforming ability of Cot results from the coordinated activation of histone H3, which ultimately converges on the regulation of the transcriptional activity of the c-fos promoter, followed by AP-1 transactivation activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.