ArticleThe Journal of experimental medicine2007
TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets.
Article in The Journal of experimental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 79 citations in OpenAlex.
- Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- A dormant T-cell population with autoimmune potential exhibits low self-reactivity and infiltrates islets in type 1 diabetes.European journal of immunology · 2022Article
- Activation pathways that drive CD4Immunological reviews · 2022Review
- Review
- HeliosEuropean journal of immunology · 2019Article
- The Lower Limit of Regulatory CD4Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Understanding Autoimmune Diabetes through the Prism of the Tri-Molecular Complex.Frontiers in endocrinology · 2017Review
- More or less-On the influence of labelling strategies to infer cell population dynamics.PloS one · 2017Article
- Developmental Progression and Interrelationship of Central and Effector Regulatory T Cell Subsets.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Conventional and Regulatory CD4+ T Cells That Share Identical TCRs Are Derived from Common Clones.PloS one · 2016Article
- Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance.Science (New York, N.Y.) · 2015Article
- Quantification of HTLV-1 clonality and TCR diversity.PLoS computational biology · 2014Article
- Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs.Immunological reviews · 2014Review
- Article
- Aire-dependent thymic development of tumor-associated regulatory T cells.Science (New York, N.Y.) · 2013Article
- Tolerogenic vaccination reduced effector memory CD4 T cells and induced effector memory Treg cells for type I diabetes treatment.PloS one · 2013Article
- Thymic versus induced regulatory T cells - who regulates the regulators?Frontiers in immunology · 2013Article
- Generation and function of induced regulatory T cells.Frontiers in immunology · 2013Article
- Targeting Tregs in Malignant Brain Cancer: Overcoming IDO.Frontiers in immunology · 2013Article
- Down syndrome, autoimmunity and T regulatory cells.Clinical and experimental immunology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Foxp3-expressing regulatory T (T reg) cells derive primarily from selection in the thymus. Yet conversion of mature conventional CD4(+) T (T conv) cell lymphocytes can be achieved in several conditions, such as transforming growth factor beta treatment, homeostatic expansion, or chronic exposure to low-dose antigen. Such conversion might provide a means to generate peripheral tolerance by "converting" potentially damaging T cells that react to self-antigens. We tested this hypothesis in mice transgenic for the BDC2.5 T cell receptor (TCR), which is representative of a diabetogenic specificity that is naturally present in NOD mice and reactive against a pancreatic self-antigen. In the thymus, before any exposure to antigen, clonotype-positive T reg and T conv cells express a second TCRalpha chain derived from endogenous loci. High-throughput single-cell sequencing of secondary TCRs of the Valpha2 family showed their joining CDR3alpha regions to be very different in T reg and T conv cell thymocytes. These specific CDR3alpha motifs, thus, provided a "tag" with which to test the actual impact of T conv to T reg cell conversion in response to peripheral self-antigen; should the autoreactive clonotypic TCR induce T conv to T reg cell conversion upon encounter of cognate antigen in the pancreas or draining lymph node, one would expect to detect tag CDR3alpha motifs from T conv cells in the T reg cell populations. Sequencing large numbers of peripheral BDC(+)Valpha2(+) cells showed that little to no conversion occurs in response to this pancreatic autoantigen.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.