ArticleThe Journal of experimental medicine2007
Thymic selection pathway regulates the effector function of CD4 T cells.
Article in The Journal of experimental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Insulin-like growth factor 2 as a driving force for exponential expansion and differentiation of the neonatal thymus.Development (Cambridge, England) · 2025Article
- NKT Cells and Other Innate T Cells: The Immune Cells That Do Not Follow the Rules.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Current insights in mouse iNKT and MAIT cell development using single cell transcriptomics data.Seminars in immunology · 2022Review
- Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells.Nature communications · 2021Article
- Invariant Natural Killer T Cell Subsets-More Than Just Developmental Intermediates.Frontiers in immunology · 2018Review
- Transcription factor networks directing the development, function, and evolution of innate lymphoid effectors.Annual review of immunology · 2015Review
- Check MAIT.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- A transgenic TCR directs the development of IL-4+ and PLZF+ innate CD4 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Bach2 maintains T cells in a naive state by suppressing effector memory-related genes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Transdifferentiation of parathyroid cells into cervical thymi promotes atypical T-cell development.Nature communications · 2013Article
- Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Innate-like CD4 T cells selected by thymocytes suppress adaptive immune responses against bacterial infections.Open journal of immunology · 2012Article
- CD4(+) T cells from MHC II-dependent thymocyte-thymocyte interaction provide efficient help for B cells.Immunology and cell biology · 2011Article
- MHC class II-restricted interaction between thymocytes plays an essential role in the production of innate CD8+ T cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Induction and maintenance of IL-4 expression are regulated differently by the 3' enhancer in CD4 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics.Immunity · 2010Article
- Raising the NKT cell family.Nature immunology · 2010Review
- Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus.Molecular immunology · 2010Article
- Generation of PLZF+ CD4+ T cells via MHC class II-dependent thymocyte-thymocyte interaction is a physiological process in humans.The Journal of experimental medicine · 2010Article
- Thymic indoleamine 2,3-dioxygenase-positive eosinophils in young children: potential role in maturation of the naive immune system.The American journal of pathology · 2009Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Recently, a new developmental pathway for CD4 T cells that is mediated by major histocompatibility complex class II-positive thymocytes was identified (Choi, E.Y., K.C. Jung, H.J. Park, D.H. Chung, J.S. Song, S.D. Yang, E. Simpson, and S.H. Park. 2005. Immunity. 23:387-396; Li, W., M.G. Kim, T.S. Gourley, B.P. McCarthy, D.B. Sant'angelo, and C.H. Chang. 2005. Immunity. 23:375-386). We demonstrate that thymocyte-selected CD4 (T-CD4) T cells can rapidly produce interferon gamma and interleukin (IL) 4 upon in vivo and in vitro T cell receptor stimulation. These T-CD4 T cells appear to be effector cells producing both T helper type 1 (Th1) and Th2 cytokines, and they maintain a potential to produce Th2 cytokines under Th1-skewing conditions in a signal transducer and activator of transcription 6-independent manner. The IL-4 mRNA level is high in CD4 single-positive thymocytes if they are selected on thymocytes, which is at least partly caused by enhanced histone acetylation of the IL-4 locus. However, mice that can generate T-CD4 T cells showed attenuated immune responses in an allergen-induced airway inflammation model, suggesting a protective role for T-CD4 T cells during an airway challenge. Our results imply that this thymic selection pathway plays an important role in determining the effector function of the resulting CD4 cells and in regulating immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.