ReviewHearing research2007
A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns.
Review in Hearing research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review on the contribution of DNA methylation to hearing loss.Clinical epigenetics · 2024Pooled it
- Bmi1 controls auditory sensory epithelial cell proliferation through genome-wide H3K27me3 modifications.Epigenetics & chromatin · 2025Article
- Article
- Exploring biomarkers for noise-induced hearing loss through mitochondrial DNA methylation analysis.Frontiers in pharmacology · 2025Article
- Function of Brain-Derived Neurotrophic Factor in the Vestibular-Cochlear System.Neurochemical research · 2024Review
- Lack of Methylation Changes inActa medica Philippina · 2023Article
- Targeting the Limbic System: Insights into Its Involvement in Tinnitus.International journal of molecular sciences · 2023Review
- Genetics & Epigenetics of Hereditary Deafness: An Historical Overview.Audiology research · 2021Article
- DNA Methylation Signature in Mononuclear Cells and Proinflammatory Cytokines May Define Molecular Subtypes in Sporadic Meniere Disease.Biomedicines · 2021Article
- Age-related hearing loss pertaining to potassium ion channels in the cochlea and auditory pathway.Pflugers Archiv : European journal of physiology · 2021Review
- Autophagy: A Novel Horizon for Hair Cell Protection.Neural plasticity · 2021Review
- Review
- Presbycusis: An Update on Cochlear Mechanisms and Therapies.Journal of clinical medicine · 2020Review
- Article
- Meclofenamic Acid Reduces Reactive Oxygen Species Accumulation and Apoptosis, Inhibits Excessive Autophagy, and Protects Hair Cell-Like HEI-OC1 Cells From Cisplatin-Induced Damage.Frontiers in cellular neuroscience · 2018Article
- MicroRNA-183 Family in Inner Ear: Hair Cell Development and Deafness.Journal of audiology & otology · 2016Review
- The epigenetic modifier DNMT3A is necessary for proper otic placode formation.Developmental biology · 2016Article
- Genetics of Tinnitus: An Emerging Area for Molecular Diagnosis and Drug Development.Frontiers in neuroscience · 2016Review
- Gene expression profiling of DBA/2J mice cochleae treated with l-methionine and valproic acid.Genomics data · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Epigenetics is a large and diverse field encompassing a number of different mechanisms essential to development, DNA stability and gene expression. DNA methylation and histone modifications work individually and in conjunction with each other leading to phenotypic changes. An overwhelming amount of evidence exists demonstrating the essential nature of epigenetics to human biology and pathology. This field has spawned a vast array of knowledge, techniques and pharmaceuticals designed to investigate and manipulate epigenetic phenomena. Despite its centricity to molecular biology, little work has been conducted examining how epigenetics affects hearing. In this review, we discuss both the basic tenets of epigenetics and highlight the most recent advances in this field. We discuss its importance to human development, genomic stability, gene expression, epigenetic modifying agents as well as briefly introduce the expansive field of cancer epigenetics. We then examine the evidence of a role for epigenetics in hearing related processes and hearing loss. The article concludes with a discussion of areas of epigenetic research that could be applied to hearing research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.