Evidence map›Paper›PMID 17722646›Full record

ReviewJournal of physiology and biochemistry2007

Using genomics to understand intestinal biology.

J C Fleet

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of physiology and biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Biomarkers of human gastrointestinal tract regions.Mammalian genome : official journal of the International Mammalian Genome Society · 2009
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

J C FleetDepartment of Foods and Nutrition and Interdepartmental Nutrition Program, Purdue University, 700 West State St., West Lafayette, IN 47906-2059, USA. fleet@purdue.edu
Purdue University West Lafayette · US

Funding

ROLE OF VDR LEVEL IN VITAMIN D-MEDIATED CA ABSORPTIONR01DK054111 · NIDDK · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI FLEET, JAMES C. · 1997 to 2012
$3.2M
NIDDK NIH HHS R01 DK054111
6 · The paper itself

Abstract

The use of microarrays to evaluate the transcriptome has transformed our view of biology. In addition to the focused, hypothesis-testing studies that we have traditionally conducted in cell biology, we are now able to see global changes within the entire system of the cell in response to a treatment. By examining a biological question under multiple complementary perturbations model systems (e.g. yeast, C. Elegans) have revealed new complexity that would have been impossible to see on a gene-by-gene approach. Unfortunately, beyond the use of transcript profiles to define the molecular signature of diseases (e.g. cancer), transcriptomics has not been extensively used to study intestinal biology. This review will provide a roadmap for effective use of gene expression profiling for biological research and will review some of the microarray work that has been done to better understand the nature of intestinal development and enterocyte differentiation.

Indexed as

Gene Expression ProfilingGenomicsAnimalsCell DifferentiationCluster AnalysisEnterocytesHumansIntestinal MucosaIntestinesModels, BiologicalOligonucleotide Array Sequence Analysis

Identifiers

PMID17722646
OpenAlexW2003111634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.