ArticleWorld journal of surgery2007
Lymph node metastasis density and growth pattern as independent prognostic factors in advanced esophageal squamous cell carcinoma.
Article in World journal of surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 65 citations in OpenAlex.
- Neoadjuvant chemotherapy of triplet regimens of docetaxel/cisplatin/5-FU (DCF NAC) may improve patient prognosis of cStage II/III esophageal squamous cell carcinoma-propensity score analysis.General thoracic and cardiovascular surgery · 2016Trial
- Lymph node ratio is a critical prognostic predictor in gastric cancer treated with S-1 chemotherapy.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2014Trial
- Lymph-node ratio as a risk factor for recurrence following neoadjuvant docetaxel, cisplatin, and 5-fluorouracil therapy for locally advanced esophageal squamous cell carcinoma.Esophagus : official journal of the Japan Esophageal Society · 2025Article
- Effective Predictor Factors for Lymph Node Metastasis and Survival in Patients with Betel Nut-Related Oral Squamous Cell Carcinoma.Diagnostics (Basel, Switzerland) · 2024Article
- Type B2 vessels and infiltrative growth patterns b and c are associated with lymphatic invasion in pT1a-lamina propria mucosa esophageal squamous cell carcinoma.Esophagus : official journal of the Japan Esophageal Society · 2023Article
- A retrospective study analyzing if lymph node ratio carbon nanoparticles predict stage III rectal cancer recurrence.Frontiers in oncology · 2023Article
- Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma.Therapeutic advances in medical oncology · 2023Review
- Does anatomical location-based metastatic lymph node density affect prognosis in lung cancer patients?Interactive cardiovascular and thoracic surgery · 2021Article
- Impact of Examined Lymph Node Count and Lymph Node Density on Overall Survival of Penile Cancer.Frontiers in oncology · 2021Article
- Factors affecting lymph node sampling patterns and the impact on survival of lymph node density in patients with Wilms tumor: a Surveillance, Epidemiology, and End Result (SEER) database review.Journal of pediatric urology · 2020Article
- How many lymph nodes are enough? Assessing the adequacy of lymph node yield for staging in favorable histology wilms tumor.Journal of pediatric surgery · 2019Article
- Lymph node density as a prognostic predictor in patients with betel nut-related oral squamous cell carcinoma.Clinical oral investigations · 2018Article
- Prognostic value of the lymph node ratio in oropharyngeal carcinoma stratified for HPV-status.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Article
- The prognostic value of lymph node ratio in survival of head-and-neck squamous cell carcinoma.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Article
- Lymph Node Ratio as a Risk Factor for Recurrence After Adjuvant Chemotherapy in Stage III Colorectal Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Article
- Lymph node ratio predicts survival in hypopharyngeal cancer with positive lymph node metastasis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Characteristics of Postoperative Recurrence in Lymph Node-Negative Superficial Esophageal Carcinoma.World journal of surgery · 2016Article
- Lymph node density is a prognostic factor in patients with major salivary gland carcinoma.Oncology letters · 2015Article
- Lymph node ratio as a prognostic factor in head and neck cancer patients.Radiation oncology (London, England) · 2015Article
- Overexpression of AKIP1 promotes angiogenesis and lymphangiogenesis in human esophageal squamous cell carcinoma.Oncogene · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEsophageal cancer is one of the leading types of cancer, and it is a particularly deadly form of malignancy. TNM classification is the most common staging system, but it has been reported that prognosis is not reflected adequately by this classification. The purpose of this study was to clarify independent prognostic factors in esophageal squamous cell carcinoma (ESCC), a dominant type of esophageal cancer in Japan, to broaden the staging system to improve its predictive value. Thus staging could be expanded to make the prognosis a valuable clinical tool, and to improve knowledge of the biological traits of advanced ESCC.
methodsThe present study included 121 patients with advanced ESCC (stage II to IVA) treated by esophagectomy between 1990 and 2003 at the Kitasato University Higashi Hospital.
resultsUnivariate prognostic analysis of the disease-specific survival revealed that TNM stage (p < 0.0001), lymph node metastasis density over 10% (ND10; p < 0.0001), R-category (p = 0.003), intramural metastasis within the esophagus (IM; p = 0.009), growth pattern (p = 0.01), and size of tumor (p = 0.02) were significantly associated with a poor outcome in advanced ESCC. Multivariate analysis confirmed that growth pattern (p = 0.02, HR = 3.1) and ND10 (p = 0.02, HR = 2.0) were finally remnant prognostic factors independent of TNM stage. Growth pattern was prominent in stage II, whereas ND10 was directly proportional to stage progression and characteristics to stage IV disease. Interestingly, ND20, the most malignant phenotype of ESCC, was the only prognostic determinant, even in stage IV disease.
conclusionsFrom the present study, we concluded that progression of lymph node density is characteristic of a life-threatening phenotype of advanced ESCC, and it should be employed as a therapeutic target to improve patient survival. Growth pattern is an alternative target characteristic of less advanced ESCC. Both of these parameters may be applied as useful clinical tools in the management of patients with advanced esophageal cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.