ArticleGenetics2007
Association of polymorphisms in odorant-binding protein genes with variation in olfactory response to benzaldehyde in Drosophila.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 55 citations in OpenAlex.
- Olfactory Decline in Elderly at High Altitudes: A Narrative Review.International journal of general medicine · 2026Review
- Chromosome-level genome assembly of the synanthropic fly Chrysomya megacephala: insights into oviposition location.BMC genomics · 2025Article
- Stage-resolved transcriptomic profiling ofFrontiers in insect science · 2025Article
- Mechanisms of Variability Underlying Odor-Guided Locomotion.Frontiers in behavioral neuroscience · 2022Review
- Natural selection on sleep duration in Drosophila melanogaster.Scientific reports · 2020Article
- Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster.Behavior genetics · 2019Article
- Evidence of peripheral olfactory impairment in the domestic silkworms: insight from the comparative transcriptome and population genetics.BMC genomics · 2018Article
- Functional Characteristics, Electrophysiological and Antennal Immunolocalization of General Odorant-Binding Protein 2 in Tea Geometrid, Ectropis obliqua.International journal of molecular sciences · 2018Article
- Artificial selection for odor-guided behavior in Drosophila reveals changes in food consumption.BMC genomics · 2017Article
- A nonrandom subset of olfactory genes is associated with host preference in the fruit flyEvolution letters · 2017Article
- Head Transcriptomes of Two Closely Related Species of Fruit Flies of the Anastrepha fraterculus Group Reveals Divergent Genes in Species with Extensive Gene Flow.G3 (Bethesda, Md.) · 2016Article
- Obp56h Modulates Mating Behavior in Drosophila melanogaster.G3 (Bethesda, Md.) · 2016Article
- Molecular evolution of Odorant-binding proteins gene family in two closely related Anastrepha fruit flies.BMC evolutionary biology · 2016Article
- Reference genes for accessing differential expression among developmental stages and analysis of differential expression of OBP genes in Anastrepha obliqua.Scientific reports · 2016Article
- The genetic basis for variation in olfactory behavior in Drosophila melanogaster.Chemical senses · 2015Article
- Article
- Sounds of silence: synonymous nucleotides as a key to biological regulation and complexity.Nucleic acids research · 2013Review
- Analysis of natural variation reveals neurogenetic networks for Drosophila olfactory behavior.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Effect of regulatory architecture on broad versus narrow sense heritability.PLoS computational biology · 2013Article
- Uncovering the functional constraints underlying the genomic organization of the odorant-binding protein genes.Genome biology and evolution · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Adaptive evolution of animals depends on behaviors that are essential for their survival and reproduction. The olfactory system of Drosophila melanogaster has emerged as one of the best characterized olfactory systems, which in addition to a family of odorant receptors, contains an approximately equal number of odorant-binding proteins (OBPs), encoded by a multigene family of 51 genes. Despite their abundant expression, little is known about their role in chemosensation, largely due to the lack of available mutations in these genes. We capitalized on naturally occurring mutations (polymorphisms) to gain insights into their functions. We analyzed the sequences of 13 Obp genes in two chromosomal clusters in a population of wild-derived inbred lines, and asked whether polymorphisms in these genes are associated with variation in olfactory responsiveness. Four polymorphisms in 3 Obp genes exceeded the statistical permutation threshold for association with responsiveness to benzaldehyde, suggesting redundancy and/or combinatorial recognition by these OBPs of this odorant. Model predictions of alternative pre-mRNA secondary structures associated with polymorphic sites suggest that alterations in Obp mRNA structure could contribute to phenotypic variation in olfactory behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.