ArticleApplied and environmental microbiology2007
Microarray-based characterization of the Listeria monocytogenes cold regulon in log- and stationary-phase cells.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Bioprotective Strategies to ControlInternational journal of molecular sciences · 2025Review
- Review
- The Genetic Determinants ofGenes · 2025Review
- Role of cold shock proteins B and D inInfection and immunity · 2024Article
- Revisiting old friends: updates on the role of two-component signaling systems inInfection and immunity · 2024Review
- Stress Adaptation Responses of aFoods (Basel, Switzerland) · 2023Article
- Comparison of genetic variations between high- and low-riskFrontiers in microbiology · 2023Article
- Functional Genomics Identified Novel Genes Involved in Growth at Low Temperatures in Listeria monocytogenes.Microbiology spectrum · 2022Article
- Genomic Analysis of Two Representative Strains ofFoods (Basel, Switzerland) · 2022Article
- Roles of Alternative Sigma Factors in Invasion and Growth Characteristics ofFrontiers in microbiology · 2022Article
- Review
- Pathogenicity and virulence ofVirulence · 2021Article
- Review
- Adaptive Response ofFrontiers in microbiology · 2021Review
- Dual Transcriptional Profile ofPathogens (Basel, Switzerland) · 2019Article
- Article
- Resistance ofFrontiers in microbiology · 2018Review
- RNA- and protein-mediated control of Listeria monocytogenes virulence gene expression.RNA biology · 2017Review
- Cold-Shock Domain Family Proteins (Csps) Are Involved in Regulation of Virulence, Cellular Aggregation, and Flagella-Based Motility inFrontiers in cellular and infection microbiology · 2017Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
Whole-genome microarray experiments were performed to define the Listeria monocytogenes cold growth regulon and to identify genes differentially expressed during growth at 4 and 37 degrees C. Microarray analysis using a stringent cutoff (adjusted P < 0.001; >/=2.0-fold change) revealed 105 and 170 genes that showed higher transcript levels in logarithmic- and stationary-phase cells, respectively, at 4 degrees C than in cells grown at 37 degrees C. A total of 74 and 102 genes showed lower transcript levels in logarithmic- and stationary-phase cells, respectively, grown at 4 degrees C. Genes with higher transcript levels at 4 degrees C in both stationary- and log-phase cells included genes encoding a two-component response regulator (lmo0287), a cold shock protein (cspL), and two RNA helicases (lmo0866 and lmo1722), whereas a number of genes encoding virulence factors and heat shock proteins showed lower transcript levels at 4 degrees C. Selected genes that showed higher transcript levels at 4 degrees C during both stationary and log phases were confirmed by quantitative reverse transcriptase PCR. Our data show that (i) a large number of L. monocytogenes genes are differentially expressed at 4 and 37 degrees C, with more genes showing higher transcript levels than lower transcript levels at 4 degrees C, (ii) L. monocytogenes genes with higher transcript levels at 4 degrees C include a number of genes and operons with previously reported or plausible roles in cold adaptation, and (iii) L. monocytogenes genes with lower transcript levels at 4 degrees C include a number of virulence and virulence-associated genes as well as some heat shock genes.
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