ArticleJournal of bacteriology2007
Abh and AbrB control of Bacillus subtilis antimicrobial gene expression.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 106 citations in OpenAlex.
- Enhancing Yields and Extending Production Cycles of Bacteriocin from theMicroorganisms · 2026Article
- Comprehensive mapping of transcription terminator Rho utilization (Rut) sites across the Bacillus subtilis genome.Nucleic acids research · 2025Article
- The extracytoplasmic sigma factor σScientific reports · 2025Article
- Subtilosin A production is influenced by surfactin levels inmicroLife · 2025Article
- Abh, AbrB3, and Spo0A play distinct regulatory roles during polymyxin synthesis inMicrobiology spectrum · 2024Article
- GeF-seq: A Simple Procedure for Base-Pair Resolution ChIP-seq.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Exploring and Engineering Novel Strong Promoters for High-Level Protein Expression inMicroorganisms · 2023Article
- The alternative sigma factor SigN ofJournal of bacteriology · 2023Article
- Metabolic inputs in the probiotic bacterium Lacticaseibacillus rhamnosus contribute to cell-wall remodeling and increased fitness.NPJ biofilms and microbiomes · 2023Article
- Extensive cellular multi-tasking withinmSystems · 2023Article
- Enhancing surfactin production in B. velezensis Bs916 combined cumulative mutagenesis and expression key enzymes.Applied microbiology and biotechnology · 2023Article
- Genome Sequencing and Genetic Engineering Reveal the Contribution of Bacitracin Produced by Bacillus paralicheniformis CPL618 to Anti-Staphylococcus aureus Activity.Current microbiology · 2023Article
- Termination factor Rho mediates transcriptional reprogramming of Bacillus subtilis stationary phase.PLoS genetics · 2023Article
- The Physiological Functions of AbrB on Sporulation, Biofilm Formation and Carbon Source Utilization inBioengineering (Basel, Switzerland) · 2022Article
- Defining the Expression, Production, and Signaling Roles of Specialized Metabolites during Bacillus subtilis Differentiation.Journal of bacteriology · 2021Article
- Influence of B. subtilis 3NA mutations in spo0A and abrB on surfactin production in B. subtilis 168.Microbial cell factories · 2021Article
- Extracellular lipopeptide bacillomycin L regulates serial expression of genes for modulating multicellular behavior in Bacillus velezensis Bs916.Applied microbiology and biotechnology · 2021Article
- A native conjugative plasmid confers potential selective advantages to plant growth-promoting Bacillus velezensis strain GH1-13.Communications biology · 2021Article
- Article
- Oxygen-Limiting Growth Conditions and Deletion of the Transition State Regulator Protein Abrb in Bacillus subtilis 6633 Result in an Increase in Subtilosin Production and a Decrease in Subtilin Production.Probiotics and antimicrobial proteins · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The Bacillus subtilis abh gene encodes a protein whose N-terminal domain has 74% identity to the DNA-binding domain of the global regulatory protein AbrB. Strains with a mutation in abh showed alterations in the production of antimicrobial compounds directed against some other Bacillus species and gram-positive microbes. Relative to its wild-type parental strain, the abh mutant was found deficient, enhanced, or unaffected for the production of antimicrobial activity. Using lacZ fusions, we examined the effects of abh upon the expression of 10 promoters known to be regulated by AbrB, including five that transcribe well-characterized antimicrobial functions (SdpC, SkfA, TasA, sublancin, and subtilosin). For an otherwise wild-type background, the results show that Abh plays a negative regulatory role in the expression of four of the promoters, a positive role for the expression of three, and no apparent regulatory role in the expression of the other three promoters. Binding of AbrB and Abh to the promoter regions was examined using DNase I footprinting, and the results revealed significant differences. The transcription of abh is not autoregulated, but it is subject to a degree of AbrB-afforded negative regulation. The results indicate that Abh is part of the complex interconnected regulatory system that controls gene expression during the transition from active growth to stationary phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.