ArticleJournal of bacteriology2007
Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 101 citations in OpenAlex.
- The Quorum Sensing-Controlled Competence Regulon Drives HACS infectious diseases · 2025Article
- Comparative analysis of theFrontiers in microbiology · 2025Article
- A nisin-inducible chromosomal gene expression system based on ICE Tn5253 of Streptococcus pneumoniae, transferable among streptococci and enterococci.World journal of microbiology & biotechnology · 2024Article
- Effects of glucose and lactate onMicrobiology spectrum · 2024Article
- Revisiting the Multifaceted Roles of Bacteriocins : The Multifaceted Roles of Bacteriocins.Microbial ecology · 2024Review
- Investigating theMicrobiology (Reading, England) · 2022Article
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- Multiplex Imaging of Polymicrobial Communities-Murine Models to Study Oral Microbiome Interactions.Methods in molecular biology (Clifton, N.J.) · 2020Article
- An intramembrane sensory circuit monitors sortase A-mediated processing of streptococcal adhesins.Science signaling · 2019Article
- Streptococcus endopeptidases promote HPV infection in vitro.MicrobiologyOpen · 2019Article
- Competence inFrontiers in cellular and infection microbiology · 2019Review
- Genetics ofMicrobiology spectrum · 2019Article
- Role of Neuraminidase-Producing Bacteria in Exposing Cryptic Carbohydrate Receptors for Streptococcus gordonii Adherence.Infection and immunity · 2018Article
- High-resolution profiles of the Streptococcus mitis CSP signaling pathway reveal core and strain-specific regulated genes.BMC genomics · 2018Article
- Mobilization of Bacteriocins during Competence in Streptococci.Trends in microbiology · 2018Article
- Gene expression of bacterial collagenolytic proteases in root caries.Journal of oral microbiology · 2018Article
- Hidden Gems in the Transcriptome Maps of Competent Streptococci.Frontiers in molecular biosciences · 2018Article
- Murein Hydrolase LytF of Streptococcus sanguinis and the Ecological Consequences of Competence Development.Applied and environmental microbiology · 2017Article
- Streptococcus gordonii pheromone s.g.cAM373 may influence the reservoir of antibiotic resistance determinants of Enterococcus faecalis origin in the oral metagenome.Journal of medical microbiology · 2017Article
- Transcriptome analysis of Streptococcus gordonii Challis DL1 indicates a role for the biofilm-associated fruRBA operon in response to Candida albicans.Molecular oral microbiology · 2016Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Streptococcus gordonii is a primary colonizer of the multispecies biofilm on tooth surfaces forming dental plaque and a potential agent of endocarditis. The recent completion of the genome sequence of the naturally competent strain Challis allowed the design of a spotted oligonucleotide microarray to examine a genome-wide response of this organism to environmental stimuli such as signal peptides. Based on temporal responses to synthetic competence signaling peptide (CSP) as indicated by transformation frequencies, the S. gordonii transcriptome was analyzed at various time points after CSP exposure. Microarray analysis identified 35 candidate early genes and 127 candidate late genes that were up-regulated at 5 and 15 min, respectively; these genes were often grouped in clusters. Results supported published findings on S. gordonii competence, showing up-regulation of 12 of 16 genes that have been reported to affect transformation frequencies in this species. Comparison of CSP-induced S. gordonii transcriptomes to results published for Streptococcus pneumoniae strains identified both conserved and species-specific genes. Putative intergenic regulatory sites, such as the conserved combox sequence thought to be a binding site for competence sigma factor, were found preceding S. gordonii late responsive genes. In contrast, S. gordonii early CSP-responsive genes were not preceded by the direct repeats found in S. pneumoniae. These studies provide the first insights into a genome-wide transcriptional response of an oral commensal organism. They offer an extensive analysis of transcriptional changes that accompany competence in S. gordonii and form a basis for future intra- and interspecies comparative analyses of this ecologically important phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.