ArticlePlant physiology2007
Flavonoids are differentially taken up and transported long distances in Arabidopsis.
Article in Plant physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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Who cites it
91 citing papers in PubMed, 258 citations in OpenAlex.
- A high-throughput fluorescence-based microplate reader assay to quantify total flavonol levels in plant tissues.Plant methods · 2026Article
- Antioxidant properties of dihydroxy B-ring flavonoids modulate circadian amplitude inLife science alliance · 2025Article
- Inhibition of DCL4 activity by maternally supplied flavonoid aglycons induces a bicolor pattern in the saddle soybean seed coat.The Plant journal : for cell and molecular biology · 2025Article
- Co-Cultivation with Azolla Affects the Metabolome of Whole Rice Plant Beyond Canonical Inorganic Nitrogen Fertilization.Rice (New York, N.Y.) · 2025Article
- Metabolomic Analysis Provides Insights into Bud Paradormancy inInternational journal of molecular sciences · 2025Article
- Physiological and transcriptional analyses of Arabidopsis primary root growth in response to phosphate starvation under light and dark conditions.Frontiers in plant science · 2025Article
- Megagametophyte maturation dynamics and flavonol changes duringFrontiers in plant science · 2025Article
- Unlocking the potential of flavonoid biosynthesis through integrated metabolic engineering.Frontiers in plant science · 2025Review
- Dual nematode infection in Brassica nigra affects shoot metabolome and aphid survival in distinct contrast to single-species infection.Journal of experimental botany · 2024Article
- Engineered coumarin accumulation reduces mycotoxin-induced oxidative stress and disease susceptibility.Plant biotechnology journal · 2023Article
- Transcriptomic analysis reveals GAMolecular genetics and genomics : MGG · 2023Article
- Transcriptomic and Metabolomic Analyses Reveal the Roles of Flavonoids and Auxin on Peanut Nodulation.International journal of molecular sciences · 2023Article
- Yellow Petal locus GaYP promotes flavonol biosynthesis and yellow coloration in petals of Asiatic cotton (Gossypium arboreum).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Short-term transcriptomic analysis at organ scale reveals candidate genes involved in low N responses in NUE-contrasting tomato genotypes.Frontiers in plant science · 2023Article
- Review
- Foliar and Root Comparative Metabolomics and Phenolic Profiling of Micro-Tom Tomato (Plants (Basel, Switzerland) · 2022Article
- Metabolic Profiles Reveal Changes in the Leaves and Roots of Rapeseed (International journal of molecular sciences · 2022Article
- Mutations that alter Arabidopsis flavonoid metabolism affect the circadian clock.The Plant journal : for cell and molecular biology · 2022Article
- Biochemistry and Molecular Basis of Intracellular Flavonoid Transport in Plants.Plants (Basel, Switzerland) · 2022Review
- Metabolic Circuits in Sap Extracts Reflect the Effects of a Microbial Biostimulant on Maize Metabolism under Drought Conditions.Plants (Basel, Switzerland) · 2022Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavonoids are synthesized in response to developmental and environmental signals and perform many functions in plants. Arabidopsis (Arabidopsis thaliana) roots grown in complete darkness do not accumulate flavonoids since the expression of genes encoding enzymes of flavonoid biosynthesis is light dependent. Yet, flavonoids accumulate in root tips of plants with light-grown shoots and light-shielded roots, consistent with shoot-to-root flavonoid movement. Using fluorescence microscopy, a selective flavonoid stain, and localized aglycone application to transparent testa mutants, we showed that flavonoids accumulated in tissues distal to the application site, indicating uptake and movement systems. This was confirmed by time-course fluorescence experiments and high-performance liquid chromatography. Flavonoid applications to root tips resulted in basipetal movement in epidermal layers, with subsequent fluorescence detected 1 cm from application sites after 1 h. Flavonoid application to midroot or cotyledons showed movement of flavonoids toward the root tip mainly in vascular tissue. Naringenin, dihydrokaempferol, and dihydroquercetin were taken up at the root tip, midroot, or cotyledons and traveled long distances via cell-to-cell movement to distal tissues, followed by conversion to quercetin and kaempferol. In contrast, kaempferol and quercetin were only taken up at the root tip. Using ATP-binding cassette (ABC) transporter and H(+)-ATPase inhibitors suggested that a multidrug resistance-associated protein ABCC transporter facilitated flavonoid movement away from the application site.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.