ArticleBiophysical journal2007
The dynamic orientation of membrane-bound peptides: bridging simulations and experiments.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Light-controlled inhibition of Gram-positive bacteria by photoswitchable amphiphilic lipids (PALs).RSC medicinal chemistry · 2026Article
- Unlocking the specificity of antimicrobial peptide interactions for membrane-targeted therapies.Computational and structural biotechnology journal · 2024Article
- Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.Biophysical journal · 2019Article
- Transmembrane Helix Integrity versus Fraying To Expose Hydrogen Bonds at a Membrane-Water Interface.Biochemistry · 2019Article
- Influence of High pH and Cholesterol on Single Arginine-Containing Transmembrane Peptide Helices.Biochemistry · 2016Article
- Juxta-terminal Helix Unwinding as a Stabilizing Factor to Modulate the Dynamics of Transmembrane Helices.Chembiochem : a European journal of chemical biology · 2016Article
- Interactions of amino acid side-chain analogs within membrane environments.The journal of physical chemistry. B · 2015Article
- Comparisons of interfacial Phe, Tyr, and Trp residues as determinants of orientation and dynamics for GWALP transmembrane peptides.Biochemistry · 2014Article
- 3D hydrophobic moment vectors as a tool to characterize the surface polarity of amphiphilic peptides.Biophysical journal · 2014Article
- Single tryptophan and tyrosine comparisons in the N-terminal and C-terminal interface regions of transmembrane GWALP peptides.The journal of physical chemistry. B · 2013Article
- Canonical azimuthal rotations and flanking residues constrain the orientation of transmembrane helices.Biophysical journal · 2013Article
- Buried lysine, but not arginine, titrates and alters transmembrane helix tilt.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Properties of membrane-incorporated WALP peptides that are anchored on only one end.Biochemistry · 2012Article
- Comparative analysis of the orientation of transmembrane peptides using solid-state (2)H- and (15)N-NMR: mobility matters.European biophysics journal : EBJ · 2012Article
- Tyrosine replacing tryptophan as an anchor in GWALP peptides.Biochemistry · 2012Article
- Probing the lipid-protein interface using model transmembrane peptides with a covalently linked acyl chain.Biophysical journal · 2011Article
- Molecular dynamics simulation of Bombolitin II in the dipalmitoylphosphatidylcholine membrane bilayer.Biophysical journal · 2011Article
- Response of GWALP transmembrane peptides to changes in the tryptophan anchor positions.Biochemistry · 2011Article
- Solid-state NMR ensemble dynamics as a mediator between experiment and simulation.Biophysical journal · 2011Article
- Orientation and dynamics of synthetic transbilayer polypeptides containing GpATM dimerization motifs.Biophysical journal · 2011Article
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2 authors.
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Abstract
The structural organization in a peptide/membrane supramolecular complex is best described by knowledge of the peptide orientation plus its time-dependent and spatial fluctuations. The static orientation, defined by the peptide tilt and a rotation about its molecular axis, is accessible through a number of spectroscopic methods. However, peptide dynamics, although relevant to understand the functionality of these systems, remains largely unexplored. Here, we describe the orientation and dynamics of Trp-flanked and Lys-flanked hydrophobic peptides in a lipid bilayer from molecular dynamics simulations. A novel view is revealed, where collective nontrivial distributions of time-evolving and ensemble peptide orientations closely represent the systems as studied experimentally. Such global distributions are broad and unveil the existence of orientational states, which depend on the anchoring mode of interfacial residues. We show that this dynamics modulates (2)H quadrupolar splittings and introduces ambiguity in the analysis of NMR data. These findings demonstrate that structural descriptions of peptide/membrane complexes are incomplete, and in cases even imprecise, without knowledge of dynamics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.