ArticleBiochimica et biophysica acta2007
Three autocrine feedback loops determine HIF1 alpha expression in chronic hypoxia.
Article in Biochimica et biophysica acta, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- The Pro-Metastatic Roles of ROS.Antioxidants (Basel, Switzerland) · 2026Review
- Mechanism of FoxO1 in the Metabolic Shift of Fetal Rat Heart.Molecules (Basel, Switzerland) · 2026Article
- The Bidirectional Role of Hypoxia-Inducible Factor 1 Alpha in Vascular Dementia Caused by Chronic Cerebral Hypoperfusion.Molecular neurobiology · 2025Review
- Engineered Feedback Employing Natural Hypoxia-Responsive Factors Enhances Synthetic Hypoxia Biosensors.ACS synthetic biology · 2025Article
- Endothelial cells signaling and patterning under hypoxia: a mechanistic integrative computational model including the Notch-Dll4 pathway.Frontiers in physiology · 2024Article
- Endothelial cells signaling and patterning under hypoxia: a mechanistic integrative computational model including the Notch-Dll4 pathway.bioRxiv : the preprint server for biology · 2023Article
- Changes in gene expression patterns in postmortem human myocardial infarction.International journal of legal medicine · 2020Article
- Severe neonatal anemia increases intestinal permeability by disrupting epithelial adherens junctions.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Metabolic Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibition of HIF1α and LDHA.Circulation research · 2018Article
- Glycolytic Response to Inflammation Over Time: Role of Myeloid HIF-1alpha.Frontiers in physiology · 2018Article
- Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer.PLoS computational biology · 2015Article
- Modeling dioxygenase enzyme kinetics in familial paraganglioma.Biology open · 2015Article
- Hypoxia-inducible factor 1-α in chronic gastrointestinal ischemia.Virchows Archiv : an international journal of pathology · 2015Observational
- Role of compartmentalization on HiF-1α degradation dynamics during changing oxygen conditions: a computational approach.PloS one · 2014Article
- Hypoxia-inducible factor (HIF) network: insights from mathematical models.Cell communication and signaling : CCS · 2013Article
- Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation.Molecular biology of the cell · 2012Article
- Computational models of VEGF-associated angiogenic processes in cancer.Mathematical medicine and biology : a journal of the IMA · 2012Article
- Hemoglobin level predicts outcome for vulvar cancer patients independent of GLUT-1 and CA-IX expression in tumor tissue.Virchows Archiv : an international journal of pathology · 2010Article
- Oxygen Sensing, Cardiac Ischemia, HIF-1α and Some Emerging Concepts.Current cardiology reviews · 2010Article
- Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model.BMC systems biology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hypoxia occurs in cancer, prolonged exercise, and long-term ischemia with durations of several hours or more, and the hypoxia-inducible factor 1 (HIF1) pathway response to these conditions differs from responses to transient hypoxia. We used computational modeling, validated by experiments, to gain a quantitative, temporal understanding of the mechanisms driving HIF1 response. To test the hypothesis that HIF1 alpha protein levels during chronic hypoxia are tightly regulated by a series of molecular feedbacks, we took into account protein synthesis and product inhibition, and analyzed HIF1 system changes in response to hypoxic exposures beyond 3 to 4 h. We show how three autocrine feedback loops together regulate HIF 1 alpha hydroxylation in different microenvironments. Results demonstrate that prolyl hydroxylase, succinate and HIF1 alpha feedback determine intracellular HIF1 alpha levels over the course of hours to days. The model provides quantitative insight critical for characterizing molecular mechanisms underlying a cell's response to long-term hypoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.