ArticleGene2007
Structural characteristics of zebrafish orthologs of adaptor molecules that associate with transmembrane immune receptors.
Article in Gene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
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- Phylogenetic and structural insights into the origin of C-type lectin Mincle in vertebrates.Immunogenetics · 2025Article
- Single-cell analyses reveal early thymic progenitors and pre-B cells in zebrafish.The Journal of experimental medicine · 2022Article
- Regulatory Role of Fc Receptor in mIgMFrontiers in immunology · 2021Article
- Antigen receptor repertoires of one of the smallest known vertebrates.Science advances · 2021Article
- The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells.The Journal of experimental medicine · 2017Article
- Review
- Retention of duplicated ITAM-containing transmembrane signaling subunits in the tetraploid amphibian species Xenopus laevis.Developmental and comparative immunology · 2015Article
- Multigene families of immunoglobulin domain-containing innate immune receptors in zebrafish: deciphering the differences.Developmental and comparative immunology · 2014Review
- Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish.PLoS pathogens · 2014Article
- Induction of phagocytosis and intracellular signaling by an inhibitory channel catfish leukocyte immune-type receptor: evidence for immunoregulatory receptor functional plasticity in teleosts.Journal of innate immunity · 2014Article
- Article
- Genomic and functional characterization of the diverse immunoglobulin domain-containing protein (DICP) family.Genomics · 2012Article
- Development and characterization of anti-nitr9 antibodies.Advances in hematology · 2012Article
- The phylogenetic origins of natural killer receptors and recognition: relationships, possibilities, and realities.Immunogenetics · 2011Review
- CD3γ/δ in sea bass (Dicentrarchus labrax): Molecular characterization and expression analysis.Results in immunology · 2011Article
- Specific resistance to Pseudomonas aeruginosa infection in zebrafish is mediated by the cystic fibrosis transmembrane conductance regulator.Infection and immunity · 2010Article
- Recognition of additional roles for immunoglobulin domains in immune function.Seminars in immunology · 2010Review
- Developmental and tissue-specific expression of NITRs.Immunogenetics · 2010Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Transmembrane bound receptors comprised of extracellular immunoglobulin (Ig) or lectin domains play integral roles in a large number of immune functions including inhibitory and activating responses. The function of many of the activating receptors requires a physical interaction with an adaptor protein possessing a cytoplasmic regulatory motif. The partnering of an activating receptor with an adaptor protein relies on complementary charged residues in the two transmembrane domains. The mammalian natural killer (NK) and Fc receptors (FcR) represent two of many receptor families, which possess activating receptors that partner with adaptor proteins for signaling. Zebrafish represent a powerful experimental model for understanding developmental regulation at early stages of embryogenesis and for efficiently generating transgenic animals. In an effort to understand developmental aspects of immune receptor function, we have accessed the partially annotated zebrafish genome to identify six different adaptor molecules: Dap10, Dap12, Cd3zeta, Cd3zeta-like, FcRgamma and FcRgamma-like that are homologous to those effecting immune function in mammals. Their genomic organizations have been characterized, cDNA transcripts have been recovered, phylogenetic relationships have been defined and their cell lineage-specific expression patterns have been established.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.