ReviewCurrent opinion in microbiology2007
Dimorphism and virulence in fungi.
Review in Current opinion in microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
153 citing papers in PubMed, 280 citations in OpenAlex.
- Virulensome: a transient organelle mediating fungal virulence.Science China. Life sciences · 2026Article
- Review
- Hybrid histidine kinases and antifungal warfare in thermal dimorphic fungi.Antimicrobial agents and chemotherapy · 2026Review
- Shapeshifting fungi: How morphological transitions can influence pathogenesis.PLoS pathogens · 2026Article
- The dynamics of transposable element content in the genome of the human pathogen Histoplasma.Fungal genetics and biology : FG & B · 2026Article
- Special pathogen infections presenting with neck mass as the initial manifestation.Frontiers in cellular and infection microbiology · 2026Article
- Proteomic Changes inJournal of proteome research · 2025Article
- Transcriptional control ofmBio · 2025Article
- Species-specific circular RNA circDS-1 enhances adaptive evolution in Talaromyces marneffei through regulation of dimorphic transition.PLoS genetics · 2025Article
- Article
- The impact of phenotypic heterogeneity on fungal pathogenicity and drug resistance.FEMS microbiology reviews · 2025Review
- Disseminated Cutaneous, Osteoarticular, and Tubulointerstitial Sporotrichosis in an Immunosenescent and Diabetic Host: A Case Report.Case reports in dermatological medicine · 2025Article
- The protein kinases family in fungi: adaptability, virulence and conservation between species.Frontiers in microbiology · 2025Review
- A new psychrophilic yeast of Kriegeriaceae (Kriegeriales) isolated from lichen in the Arctic, with the description ofMycoKeys · 2025Article
- Diagnosis and management of invasive fungal diseases by next-generation sequencing: are we there yet?Expert review of molecular diagnostics · 2024Review
- Identification of Homeobox Transcription Factors in a Dimorphic FungusJournal of fungi (Basel, Switzerland) · 2024Article
- Fungal primary and opportunistic pathogens: an ecological perspective.FEMS microbiology reviews · 2024Review
- Article
- Novel Insights into Sporotrichosis and Diabetes.Journal of fungi (Basel, Switzerland) · 2024Review
- A single gene mutation underpins metabolic adaptation and acquisition of filamentous competence in the emerging fungal pathogen Candida auris.PLoS pathogens · 2024Article
93 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The signature feature of systemic dimorphic fungi - a family of six primary fungal pathogens of humans - is a temperature-induced phase transition. These fungi grow as a mold in soil at ambient temperature and convert to yeast after infectious spores are inhaled into the lungs of a mammalian host. Seminal work 20 years ago established that a temperature-induced phase transition from mold to yeast is required for virulence. Several yeast-phase specific genes, identified one-by-one and studied by reverse genetics, have revealed mechanisms by which the phase transition promotes disease pathogenesis. Transcriptional profiling of microarrays built with genomic elements of Histoplasma capsulatum and ESTs of Paracoccidioides brasiliensis that represent partial genomes has identified 500 genes and 328 genes, respectively, that are differentially expressed upon the phase transition. The genomes of most of the dimorphic fungi are now in varying stages of being sequenced. The creation of additional microarrays and the application of new reverse genetic tools promise fresh insight into genes and mechanisms that regulate pathogenesis and morphogenesis. The use of insertional mutagenesis by Agrobacterium has uncovered a hybrid histidine kinase that regulates dimorphism and pathogenicity in Blastomyces dermatitidis and H. capsulatum. Two-component signaling appears to be a common strategy for model and pathogenic fungi to sense and respond to environmental stresses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.