ArticleBrain, behavior, and immunity2008
Personality and serotonin transporter genotype interact with social context to affect immunity and viral set-point in simian immunodeficiency virus disease.
Article in Brain, behavior, and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 85 citations in OpenAlex.
- Personality trait structures across three species of Macaca, using survey ratings of responses to conspecifics and humans.PloS one · 2024Article
- Rhesus monkey sociality is stable across time and linked to variation in the initiation but not receipt of prosocial behavior.American journal of primatology · 2022Article
- Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits.International journal of molecular sciences · 2022Article
- Scaredy-cats don't succeed: behavioral traits predict problem-solving success in captive felidae.PeerJ · 2022Article
- Dissecting genetic and sex-specific sources of host heterogeneity in pathogen shedding and spread.PLoS pathogens · 2021Article
- Trio housing of adult male rhesus macaques (Macaca mulatta): Methodology and outcome predictors.Journal of medical primatology · 2020Article
- Divergent immune responses in behaviorally-inhibited vs. non-inhibited male rats.Physiology & behavior · 2020Article
- Loneliness in monkeys: Neuroimmune mechanisms.Current opinion in behavioral sciences · 2019Article
- Personality, environmental stressors, and diarrhea in Rhesus macaques: An interactionist perspective.American journal of primatology · 2018Article
- Coping style and cortisol levels in infancy predict hair cortisol following new group formation in captive rhesus macaques (Macaca mulatta).American journal of primatology · 2018Article
- Naturally Occurring Nonhuman Primate Models of Psychosocial Processes.ILAR journal · 2017Review
- Social regulation of the lymph node transcriptome in rhesus macaques (Macaca mulatta).Psychoneuroendocrinology · 2017Article
- Laboratory rhesus macaque social housing and social changes: Implications for research.American journal of primatology · 2017Review
- Untangling the Gordian knot of HIV, stress, and cognitive impairment.Neurobiology of stress · 2016Review
- Early Predictors of Impaired Social Functioning in Male Rhesus Macaques (Macaca mulatta).PloS one · 2016Article
- Effect of Indoor Compared with Outdoor Location during Gestation on the Incidence of Diarrhea in Indoor-Reared Rhesus Macaques (Macaca mulatta).Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- Connections Matter: Social Networks and Lifespan Health in Primate Translational Models.Frontiers in psychology · 2016Article
- Social instability and immunity in rhesus monkeys: the role of the sympathetic nervous system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Article
- Risk factors for stereotypic behavior and self-biting in rhesus macaques (Macaca mulatta): animal's history, current environment, and personality.American journal of primatology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
From the beginning of the AIDS epidemic, stress has been a suspected contributor to the wide variation seen in disease progression, and some evidence supports this idea. Not all individuals respond to a stressor in the same way, however, and little is known about the biological mechanisms by which variations in individuals' responses to their environment affect disease-relevant immunologic processes. Using the simian immunodeficiency virus/rhesus macaque model of AIDS, we explored how personality (Sociability) and genotype (serotonin transporter promoter) independently interact with social context (Stable or Unstable social conditions) to influence behavioral expression, plasma cortisol concentrations, SIV-specific IgG, and expression of genes associated with Type I interferon early in infection. SIV viral RNA set-point was strongly and negatively correlated with survival as expected. Set-point was also associated with expression of interferon-stimulated genes, with CXCR3 expression, and with SIV-specific IgG titers. Poorer immune responses, in turn, were associated with display of sustained aggression and submission. Personality and genotype acted independently as well as in interaction with social condition to affect behavioral responses. Together, the data support an "interactionist" perspective [Eysenck, H.J., 1991. Personality, stress and disease: an interactionist perspective. Psychol. Inquiry 2, 221-232] on disease. Given that an important goal of HIV treatment is to maintain viral set-point as low as possible, our data suggest that supplementing anti-retroviral therapy with behavioral or pharmacologic modulation of other aspects of an organism's functioning might prolong survival, particularly among individuals living under conditions of threat or uncertainty.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.