ReviewInternational journal of occupational and environmental health
Benzene-induced cancers: abridged history and occupational health impact.
Review in International journal of occupational and environmental health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- Occupational benzene exposure and risk of kidney and bladder cancers: a systematic review and meta-analysis.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2025Pooled it
- Benzene and human health: a comprehensive review of carcinogenic risks, mechanisms, and preventive strategies.Annals of medicine and surgery (2012) · 2025Review
- Method Development for Detecting Low Level Volatile Organic Compounds (VOCs) among Workers and Residents from a Carpentry Work Shop in a Palestinian Village.International journal of environmental research and public health · 2023Article
- Separation of Volatile Organic Compounds in TAMOF-1.ACS applied materials & interfaces · 2022Article
- Identification of potential pathways and microRNA-mRNA networks associated with benzene metabolite hydroquinone-induced hematotoxicity in human leukemia K562 cells.BMC pharmacology & toxicology · 2022Article
- Daphnetin: A bioactive natural coumarin with diverse therapeutic potentials.Frontiers in pharmacology · 2022Review
- Kefir milk alleviates benzene-induced immunotoxicity and hematotoxicity in rats.Environmental science and pollution research international · 2021Article
- Intermolecular π-π Stacking Interactions Made Visible.Journal of chemical education · 2021Article
- Estimation of indoor air pollutant during photocopy/printing operation: a computational fluid dynamics (CFD)-based study.Environmental geochemistry and health · 2020Article
- Association between Metabolites and the Risk of Lung Cancer: A Systematic Literature Review and Meta-Analysis of Observational Studies.Metabolites · 2020Review
- Association of environmental exposure with hematological and oxidative stress alteration in gasoline station attendants.Environmental science and pollution research international · 2019Article
- Hazardous air pollutants and primary liver cancer in Texas.PloS one · 2017Article
- A fully electronic microfabricated gas chromatograph with complementary capacitive detectors for indoor pollutants.Microsystems & nanoengineering · 2016Article
- Bioremediation of petroleum hydrocarbons from crude oil-contaminated soil with the earthworm: Hyperiodrilus africanus.3 Biotech · 2015Article
- Urine biomarker for benzene exposure and precancerous chromosome damage among gas station attendants in Bangkok, trend after implementation of declaration of standards for control of air quality.South Asian journal of cancer · 2014Article
- Over-expression of CYP2E1 mRNA and protein: implications of xenobiotic induced damage in patients with de novo acute myeloid leukemia with inv(16)(p13.1q22); CBFβ-MYH11.International journal of environmental research and public health · 2012Article
- Benzene metabolite 1,2,4-benzenetriol induces halogenated DNA and tyrosines representing halogenative stress in the HL-60 human myeloid cell line.Environmental health perspectives · 2012Article
- Evaluation of occupational exposure of shoe makers to benzene and toluene compounds in shoe manufacturing workshops in East tehran.Tanaffos · 2012Article
- Occupational exposure levels to benzene in Italy: findings from a national database.International archives of occupational and environmental health · 2011Article
- Are polymorphisms in metabolism protective or a risk for reduced white blood cell counts in a Chinese population with low occupational benzene exposures?International journal of occupational and environmental healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Benzene-induced cancer in humans was first reported in the late 1920s. Carcinogenesis findings in animals were not reported conclusively until 1979. Industry exploited this "discrepancy" to discredit the use of animal bioassays as surrogates for human exposure experience. The cardinal reason for the delay between first recognizing leukemia in humans and sought-after neoplasia in animals centers on poor design and conduct of experimental studies. The first evidence of carcinogenicity in animals manifested as malignant tumors of the zymbal glands (sebaceous glands in the ear canal) of rats, and industry attempted to discount this as being irrelevant to humans, as this organ is vestigial and not present per se in humans. Nonetheless, shortly thereafter benzene was shown to be carcinogenic to multiple organ sites in both sexes of multiple strains and multiple species of laboratory animals exposed via various routes. This paper presents a condensed history of the benzene bioassay story with mention of benzene-associated human cancers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.