ArticlePflugers Archiv : European journal of physiology2008
Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue.
Article in Pflugers Archiv : European journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 91 citations in OpenAlex.
- Fish Oil Alters the Metabolome, Antioxidative Potential, and Secretory Profile of Visceral Adipose Tissue in Mice with High-Fat Diet-Induced Obesity Compared with Other Dietary Fat Sources.Molecules (Basel, Switzerland) · 2026Article
- Changes Induced by Aging and Long-Term Exercise and/or DHA Supplementation in Muscle of Obese Female Mice.Nutrients · 2022Article
- Oestrogen replacement fails to fully revert ovariectomy-induced changes in adipose tissue monoglycerides, diglycerides and cholesteryl esters of rats fed a lard-enriched diet.Scientific reports · 2021Article
- Comparative analysis of glucose metabolism responses of large yellow croaker Larimichthys crocea fed diet with fish oil and palm oil.Fish physiology and biochemistry · 2019Article
- Differential effects of coconut versus soy oil on gut microbiota composition and predicted metabolic function in adult mice.BMC genomics · 2018Article
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- Article
- Dietary Fatty Acid Composition Modulates Obesity and Interacts with Obesity-Related Genes.Lipids · 2017Review
- The pro-/anti-inflammatory effects of different fatty acids on visceral adipocytes are partially mediated by GPR120.European journal of nutrition · 2017Article
- Fasting and postprandial regulation of the intracellular localization of adiponectin and of adipokines secretion by dietary fat in rats.Nutrition & diabetes · 2015Article
- Modulation of adipocyte differentiation by omega-3 polyunsaturated fatty acids involves the ubiquitin-proteasome system.Journal of cellular and molecular medicine · 2014Article
- Dietary fat quality in regular fat diets has minor effects on biomarkers of inflammation in obese Zucker rats.European journal of nutrition · 2014Article
- The influence of EPA and DHA on markers of inflammation in 3T3-L1 cells at different stages of cellular maturation.Lipids in health and disease · 2014Article
- Saw palmetto ethanol extract inhibits adipocyte differentiation.Journal of natural medicines · 2013Article
- Effects of a diet enriched with polyunsaturated, saturated, or trans fatty acids on cytokine content in the liver, white adipose tissue, and skeletal muscle of adult mice.Mediators of inflammation · 2013Article
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- A study on the short-term effect of cafeteria diet and pioglitazone on insulin resistance and serum levels of adiponectin and ghrelin.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Acute pancreatitis in obesity: adipokines and dietary fish oil.Digestive diseases and sciences · 2011Article
- Fatty acid-gene interactions, adipokines and obesity.European journal of clinical nutrition · 2011Review
- Supplementing alpha-tocopherol (vitamin E) and vitamin D3 in high fat diet decrease IL-6 production in murine epididymal adipose tissue and 3T3-L1 adipocytes following LPS stimulation.Lipids in health and disease · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is positively correlated to dietary lipid intake, and the type of lipid may play a causal role in the development of obesity-related pathologies. A major protein secreted by adipose tissue is adiponectin, which has antiatherogenic and antidiabetic properties. The aim of this study was to evaluate the effects of four different high-fat diets (enriched with soybean oil, fish oil, coconut oil, or lard) on adiponectin gene expression and secretion by the white adipose tissue (WAT) of mice fed on a selected diet for either 2 (acute treatment) or 60 days (chronic treatment). Additionally, 3T3-L1 adipocytes were treated for 48 h with six different fatty acids: palmitic, linoleic, eicosapentaenoic (EPA), docosahexaenoic (DHA), lauric, or oleic acid. Serum adiponectin concentration was reduced in the soybean-, coconut-, and lard-enriched diets in both groups. Adiponectin gene expression was lower in retroperitoneal WAT after acute treatment with all diets. The same reduction in levels of adiponectin gene expression was observed in epididymal adipose tissue of animals chronically fed soybean and coconut diets and in 3T3-L1 cells treated with palmitic, linoleic, EPA, and DHA acids. These results indicate that the intake of certain fatty acids may affect serum adiponectin levels in mice and adiponectin gene expression in mouse WAT and 3T3-L1 adipocytes. The effects appear to be time dependent and depot specific. It is postulated that the downregulation of adiponectin expression by dietary enrichment with soybean oil or coconut oil may contribute to the development of insulin resistance and atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.