Evidence map›Paper›PMID 17717439›Full record

Trial reportAnnals of surgery2007

The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn.

Marc G Jeschke, Celeste C Finnerty, Oscar E Suman, Gabriela Kulp, Ronald P Mlcak, David N Herndon

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 66 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 5 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03091075 naterminatednot on this mapstarted 2018, after this paper: background citation

Ability of Oral Steroid (Oxandrolone) to Halt Fatty Infiltration and Aid Rotator Cuff Healing: A Double-Blind, Randomized Clinical Trial

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2018 to 2026Enrolled4ConditionsRotator Cuff TearArmsOxandrolone, Placebo
NCT03678233 phase2unknown statusnot on this mapstarted 2019, after this paper: background citation

Efficacy of Testosterone Gel to Restore Normal Serum Values of Testosterone During the Acute Phase of Critical Illness in Adult ICU Patients

TypeinterventionalSponsorUniversity Hospital, Clermont-FerrandRan2019 to 2025Enrolled30ConditionsHypermetabolism in ICU, Loss of Muscle Mass, Functional Disability After ICU, ICU Acquired HypogonadismArmsAndroGel 16.2 mg/L
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 5 syntheses or guidelines pooled it, 176 citations in OpenAlex.

  1. Pooled it
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  5. Anabolic steroids for treating pressure ulcers.The Cochrane database of systematic reviews · 2017
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  13. Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial.American journal of respiratory and critical care medicine · 2010
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  15. Review
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  18. Article
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Marc G JeschkeShriners Hospital for Children, and Department of Surgery, University Texas Medical Branch, Galveston, Texas, USA. majeschk@utmb.edu
Celeste C Finnerty
Oscar E Suman
Gabriela Kulp
Ronald P Mlcak
David N Herndon
Shriners Hospitals for Children - Galveston · US

Funding

Project 9: The role of androgen/corticosteroid in fat, muscle and glucose metabolism of burn victimsP50GM060338 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI SZABO, CSABA · 2000 to 2017
$24.2M
MODULATION OF THE POSTBURN HYPERMETABOLIC RESPONSER01GM056687 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI HERNDON, DAVID N. · 1998 to 2017
$9.0M
Oxandrolone and Exercise: A potent therapy in the rehabilitation from burnsR01HD049471 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUMAN-VEJAS, OSCAR E. · 2006 to 2019
$5.8M
POSTDOCTORAL TRAINING IN TRAUMA &BURNST32GM008256 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Celeste Campbell Finnerty, Oscar E. Suman-Vejas · 1990 to 2026
$4.0M
Physiological Adaptations to Exercise in Burned ChildrenK01HL070451 · NHLBI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI SUMAN, OSCAR E · 2002 to 2006
$639k
NHLBI NIH HHS K01 HL070451NHLBI NIH HHS K01-HL70451NICHD NIH HHS R01 HD049471NICHD NIH HHS R01-HD049471NIGMS NIH HHS P50 GM060338NIGMS NIH HHS P50GM60338NIGMS NIH HHS R01 GM056687NIGMS NIH HHS R01-GM56687NIGMS NIH HHS T32 GM008256PHS HHS H133A020102
6 · The paper itself

Abstract

objective and summary background dataPostburn long-term oxandrolone treatment improves hypermetabolism and body composition. The effects of oxandrolone on clinical outcome, body composition, endocrine system, and inflammation during the acute phase postburn in a large prospective randomized single-center trial have not been studied.

methodsBurned children (n = 235) with >40% total body surface area burn were randomized (block randomization 4:1) to receive standard burn care (control, n = 190) or standard burn care plus oxandrolone for at least 7 days (oxandrolone 0.1 mg/kg body weight q.12 hours p.o, n = 45). Clinical parameters, body composition, serum hormones, and cytokine expression profiles were measured throughout acute hospitalization. Statistical analysis was performed by Student t test, or ANOVA followed by Bonferroni correction with significance accepted at P < 0.05.

resultsDemographics and clinical data were similar in both groups. Length of intensive care unit stay was significantly decreased in oxandrolone-treated patients (0.48 +/- 0.02 days/% burn) compared with controls (0.56 +/- 0.02 days/% burn), (P < 0.05). Control patients lost 8 +/- 1% of their lean body mass (LBM), whereas oxandrolone-treated patients had preserved LBM (+9 +/- 4%), P < 0.05. Oxandrolone significantly increased serum prealbumin, total protein, testosterone, and AST/ALT, whereas it significantly decreased alpha2-macroglobulin and complement C3, P < 0.05. Oxandrolone did not adversely affect the endocrine and inflammatory response as we found no significant differences in the hormone panels and cytokine expression profiles.

conclusionsIn this large prospective, double-blinded, randomized single-center study, oxandrolone shortened length of acute hospital stay, maintained LBM, improved body composition and hepatic protein synthesis while having no adverse effects on the endocrine axis postburn, but was associated with an increase in AST and ALT.

Indexed as

Anabolic AgentsAnalysis of VarianceBody CompositionBody Mass IndexBurnsCalorimetry, IndirectChildChi-Square DistributionCytokinesDouble-Blind MethodFemaleHormonesHumansMaleMetabolic DiseasesMuscle StrengthAnabolic AgentsCytokinesHormonesOxandroloneProteins

Identifiers

PMID17717439
PMCPMC1959346
OpenAlexW1989095986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.