ArticleThe American journal of pathology2007
Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Emergence of fibrotic pericytes and their transcriptional regulation in pulmonary fibrosis.Nature communications · 2026Article
- Simultaneous inhibition of ID1 and ID3 mitigates fibroblast activation via cell cycle and MEK/ERK pathways in pulmonary fibrosis.Theranostics · 2026Article
- Endothelial sensitivity to pro-fibrotic signals links systemic exposure to pulmonary fibrosis.Cell death & disease · 2025Article
- Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway.Cell death & disease · 2023Article
- Combination of Niclosamide and Pirfenidone Alleviates Pulmonary Fibrosis by Inhibiting Oxidative Stress and MAPK/Nf-κB and STATs Regulated Genes.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Id1 expression in kidney endothelial cells protects against diabetes-induced microvascular injury.FEBS open bio · 2020Article
- Endothelial Plasticity: Shifting Phenotypes through Force Feedback.Stem cells international · 2016Review
- Id proteins regulate capillary repair and perivascular cell proliferation following ischemia-reperfusion injury.PloS one · 2014Article
- Expression of Id proteins is regulated by the Bcl-3 proto-oncogene in prostate cancer.Oncogene · 2013Article
- Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Direct leukocyte migration across pulmonary arterioles and venules into the perivascular interstitium of murine lungs during bleomycin injury and repair.The American journal of pathology · 2011Article
- Hepatocyte growth factor in lung repair and pulmonary fibrosis.Acta pharmacologica Sinica · 2011Review
- ID family protein expression and regulation in hypoxic pulmonary hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells.Journal of cell science · 2010Article
- Bleomycin induces the extrinsic apoptotic pathway in pulmonary endothelial cells.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expression.The Journal of biological chemistry · 2008Article
- Cross talk between Id1 and its interactive protein Dril1 mediate fibroblast responses to transforming growth factor-beta in pulmonary fibrosis.The American journal of pathology · 2008Article
- Article
- Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration.Biochemical and biophysical research communications · 2008Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The Id family of genes encodes negative regulators of basic helix-loop-helix transcription factors and has been implicated in diverse cellular processes such as proliferation, apoptosis, differentiation, and migration. However, the specific role of Id1 in lung injury has not been investigated. Bleomycin has been widely used to generate animal models of acute lung injury and fibrogenesis. In this study we found that, on bleomycin challenge, Id1 expression was significantly up-regulated in the lungs, predominantly in endothelial cells, as revealed by double immunolabeling and quantitative flow cytometric analysis. Mice with Id1 loss-of-function (Id1(-/-)) displayed increased vascular permeability and endothelial apoptosis in the lungs after bleomycin-induced injury. Cultured Id1(-/-) lung microvascular endothelial cells also showed decreased survival when exposed to bleomycin. We detected a decrease in the level of Bcl-2, a primary anti-apoptotic protein, in Id1(-/-) endothelial cells, suggesting that down-regulated Bcl-2 may promote endothelial apoptosis in the lung. Therefore, we propose that Id1 plays a crucial role in promoting endothelial survival in the adult lung on injury. In addition, bleomycin-exposed Id1(-/-) mice showed increased lung collagen accumulation and fibrogenesis, suggesting that Id1 up-regulation in the lung may play a critical role in lung homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.