ArticleThe Journal of physiology2007
Temperature enhances exocytosis efficiency at the mouse inner hair cell ribbon synapse.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Response of a neuronal network computational model to infrared neural stimulation.Frontiers in computational neuroscience · 2022Article
- Encoding sound in the cochlea: from receptor potential to afferent discharge.The Journal of physiology · 2021Review
- RIM-Binding Proteins Are Required for Normal Sound-Encoding at Afferent Inner Hair Cell Synapses.Frontiers in molecular neuroscience · 2021Article
- Temperature effects on synaptic transmission and neuronal function in the visual thalamus.PloS one · 2020Article
- How to Build a Fast and Highly Sensitive Sound Detector That Remains Robust to Temperature Shifts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Synaptotagmin-1 enables frequency coding by suppressing asynchronous release in a temperature dependent manner.Scientific reports · 2019Article
- Clustered CaCell reports · 2018Article
- A Ca2+ channel differentially regulates Clathrin-mediated and activity-dependent bulk endocytosis.PLoS biology · 2017Article
- Different CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The Coupling between CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants.The EMBO journal · 2016Article
- Actin Filaments Regulate Exocytosis at the Hair Cell Ribbon Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Interplay between synchronization of multivesicular release and recruitment of additional release sites support short-term facilitation at hippocampal mossy fiber to CA3 pyramidal cells synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Spatiotemporal pattern of action potential firing in developing inner hair cells of the mouse cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Temperature enhances activation and inactivation kinetics of potassium currents in inner hair cells isolated from Guinea-pig cochlea.Clinical and experimental otorhinolaryngology · 2013Article
- New developments in understanding the mechanisms and function of spontaneous electrical activity in the developing mammalian auditory system.Journal of the Association for Research in Otolaryngology : JARO · 2012Review
- Development and function of the voltage-gated sodium current in immature mammalian cochlear inner hair cells.PloS one · 2012Article
- The diverse roles of ribbon synapses in sensory neurotransmission.Nature reviews. Neuroscience · 2010Review
- Precise temperature compensation of phase in a rhythmic motor pattern.PLoS biology · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hearing relies on fast and sustained neurotransmitter release from inner hair cells (IHCs) onto the afferent auditory nerve fibres. The temperature dependence of Ca(2+) current and transmitter release at the IHCs ribbon synapse has not been investigated thus far. To assess the influence of temperature on calcium-triggered exocytosis, patch-clamp recordings of voltage-gated L-type Ca(2+) influx and exocytic membrane capacitance changes were performed at room (25 degrees C) and physiological (35-37 degrees C) temperatures. An increase in temperature within this range increased the L-type Ca(2+) current amplitude of IHCs (Q(10) = 1.3) and accelerates the activation kinetics. Fast exocytosis, probed by 20 ms depolarization, was enhanced at physiological temperature with a Q(10) of 2.1. The amplitude of fast release was elevated disproportionately to the increase in Ca(2+) influx. In contrast, the rate of sustained exocytosis (exocytic rate between 20 and 100 ms of depolarization) did not show a significant increase at physiological temperature. Altogether, these data indicate that the efficiency of fast exocytosis is higher at physiological temperature than at room temperature and suggest that the number of readily releasable vesicles available at the active zone is higher at physiological temperature.
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