ArticleThe Journal of physiology2007
Dependence on extracellular Ca2+/K+ antagonism of inspiratory centre rhythms in slices and en bloc preparations of newborn rat brainstem.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Roflumilast, a phosphodiesterase-4 (PDE4) inhibitor, induces respiratory frequency plasticity that is resistant to inflammation in neonatal rat in vitro preparations.Respiratory physiology & neurobiology · 2025Article
- Time and dose-dependent impairment of neonatal respiratory motor activity after systemic inflammation.Respiratory physiology & neurobiology · 2020Article
- Bimodal Respiratory-Locomotor Neurons in the Neonatal Rat Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Electrophysiology on Isolated Brainstem-spinal Cord Preparations from Newborn Rodents Allows Neural Respiratory Network Output Recording.Journal of visualized experiments : JoVE · 2015Article
- Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- Distinct inspiratory rhythm and pattern generating mechanisms in the preBötzinger complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Automated cell-specific laser detection and ablation of neural circuits in neonatal brain tissue.The Journal of physiology · 2013Article
- Gestational stress promotes pathological apneas and sex-specific disruption of respiratory control development in newborn rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Understanding the rhythm of breathing: so near, yet so far.Annual review of physiology · 2013Review
- Dendritic calcium activity precedes inspiratory bursts in preBotzinger complex neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Degeneracy as a substrate for respiratory regulation.Respiratory physiology & neurobiology · 2010Review
- Opioids prolong and anoxia shortens delay between onset of preinspiratory (pFRG) and inspiratory (preBötC) network bursting in newborn rat brainstems.Pflugers Archiv : European journal of physiology · 2009Article
- Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro.The Journal of physiology · 2009Article
- Anoxic persistence of lumbar respiratory bursts and block of lumbar locomotion in newborn rat brainstem spinal cords.The Journal of physiology · 2007Article
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5 authors.
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Abstract
The pre-Bötzinger Complex (preBötC) inspiratory centre remains active in isolated brainstem-spinal cords and brainstem slices. The extent to which findings in these models depend on their dimensions or superfusate [K(+)] and [Ca(2+)] (both of which determine neuronal excitability) is not clear. We report here that inspiratory-related rhythms in newborn rat slices and brainstem-spinal cords with defined boundaries were basically similar in physiological Ca(2+) (1.2 mm) and K(+) (3 mm). Hypoglossal nerve rhythm was 1 : 1-coupled to preBötC activity in slices and to cervical nerve bursts in en bloc preparations lacking the facial motonucleus (VII). Hypoglossal rhythm was depressed in brainstems containing (portions of) VII, while pre/postinspiratory lumbar nerve bursting was present only in preparations with > 79% VII. preBötC-related slice rhythms were inhibited in 1.5 mm Ca(2+) solution, whereas their longevity and burst rate were substantially augmented in 1 mm Ca(2+). Ca(2+) depression of slice rhythms was antagonized by raising superfusate K(+) to 8-10 mm. This strong extracellular Ca(2+)/K(+) antagonism of inspiratory (motor) rhythms was also revealed in brainstem-spinal cords without VII, while the inhibition was progressively attenuated with increasing amount of rostral tissue. We hypothesize that depression of hypoglossal rhythm and decreased Ca(2+) sensitivity of preBötC rhythm are probably not related to an increased content of rostral respiratory structures, but rather to larger brainstem dimensions resulting in interstitial gradients for neuromodulator(s) and K(+), respectively. We discuss whether block of pre/postinspiratory activity in preparations with < 79% VII is due to impairment of the pathway from preinspiratory interneurons to abdominal muscles.
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